PCA3

PCA3
PCA3
식별자
별칭PCA3, DD3, NCRNA00019, PCAT3, 전립선암 관련 3(비단백 코딩), 전립선암 관련 3, PRUNE2-AS1
외부 IDOMIM: 604845 GeneCard: PCA3
직교체
종인간마우스
엔트레스

50652

n/a

앙상블

ENSG00000225937

n/a

유니프로트

n
a

n/a

RefSeq(mRNA)

n/a

n/a

RefSeq(단백질)

n/a

n/a

위치(UCSC)Cr 9: 76.69 – 76.86Mbn/a
PubMed 검색[2]n/a
위키다타
인간 보기/편집

전립선암 항원 3(PCA3, DD3)은 비코딩 RNA를 발현하는 유전자. PCA3는 인간의 전립선 조직에서만 발현되며, 전립선암에서는 이 유전자가 고도로 과압되어 있다.[3][4]제한된 표현 프로파일 때문에 PCA3 RNA는 종양 표식기로 유용하다.[5]

바이오마커로 사용

오늘날 전립선암에 가장 많이 사용되는 바이오마커는 전립선 특이 항원(PSA)의 혈청 수준 또는 파생 측정값이다.그러나 PSA는 전립선 특이적이지만 암 특이하지는 않기 때문에 불완전한 바이오마커다.예를 들어, PSA는 양성 전립선 비대증을 가진 노인들에게서 증가할 수 있다.전립선암 진단을 개선하기 위해 몇 개의 새로운 바이오마커들이 조사되고 있다.이 중 일부는 소변 샘플로 측정할 수 있으며, 향후 여러 개의 비뇨기 바이오마커 조합이 PSA를 대체할 가능성도 있다.[6]

PCA3는 혈청 PSA에 비해 감도는 낮지만 특수성이 높고 긍정적이고 부정적인 예측값이 좋다.[7]그것은 전립선 부피와는 독립적이지만, PSA는 그렇지 않다.[8]디지털 직장검사로 전립선 마사지 후 소변 1부에서 측정해야 한다.[9]

PCA3는 반복적인 전립선 조직검사를 받는 남성들에게 악성종양의 존재를 예측하는 데 유용한 것으로 나타났다.[9][10]이는 디지털 직장검사와 PSA가 전립선암 가능성을 시사하는 환자에게 임상적으로 유용할 수 있다는 것을 의미하지만, 첫 전립선 조직검사는 정상 결과를 반환한다.이는 약 60%의 사례에서 발생하며, 반복 검사 시 20-40%가 비정상적인 생체검사 결과를 가지고 있다.[11]

PCA3에 대해 연구되고 있는 다른 용도에는 종양 용적, 등급(글레이슨 점수) 또는 체외 연장 같은 이상 종양 특징과의 상관관계가 있다.이 연구들은 지금까지 상반된 결과를 낳았다.[12][13][14]

사회와 문화

Progensa PCA3 테스트라고 불리는 상업용 키트는 캘리포니아 회사 Gen-Probe에 의해 판매되고 있다.[citation needed]Gen-Probe는 2003년 진단으로부터 PCA3 테스트에 대한 권한을 취득했다.[citation needed]홀로닉은 2012년 4월 겐프로베를 현금 37억5000만달러에 인수했다.[15]

디스커버리

PCA3는 1999년 전립선암세포에 의해 고도로 발현된 것으로 밝혀졌다.[3][third-party source needed]

참조

  1. ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000225937 - 앙상블, 2017년 5월
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b Bussemakers MJ, van Bokhoven A, Verhaegh GW, Smit FP, Karthaus HF, Schalken JA, Debruyne FM, Ru N, Isaacs WB (December 1999). "DD3: a new prostate-specific gene, highly overexpressed in prostate cancer". Cancer Research. 59 (23): 5975–9. PMID 10606244.
  4. ^ Neves AF, Araújo TG, Biase WK, Meola J, Alcântara TM, Freitas DG, Goulart LR (October 2008). "Combined analysis of multiple mRNA markers by RT-PCR assay for prostate cancer diagnosis". Clinical Biochemistry. 41 (14–15): 1191–8. doi:10.1016/j.clinbiochem.2008.06.013. PMID 18640109.
  5. ^ Loeb S (November 2008). "Does PCA3 help identify clinically significant prostate cancer?". European Urology. 54 (5): 980–1. doi:10.1016/j.eururo.2008.07.027. PMID 18684556.
  6. ^ Laxman B, Morris DS, Yu J, Siddiqui J, Cao J, Mehra R, Lonigro RJ, Tsodikov A, Wei JT, Tomlins SA, Chinnaiyan AM (February 2008). "A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer". Cancer Research. 68 (3): 645–9. doi:10.1158/0008-5472.CAN-07-3224. PMC 2998181. PMID 18245462.
  7. ^ Vlaeminck-Guillem V, Ruffion A, Andre J (May 2008). "[Value of urinary PCA3 test for prostate cancer diagnosis]". Progres en Urologie (in French). 18 (5): 259–65. doi:10.1016/j.purol.2008.03.029. PMID 18538269.
  8. ^ Deras IL, Aubin SM, Blase A, Day JR, Koo S, Partin AW, Ellis WJ, Marks LS, Fradet Y, Rittenhouse H, Groskopf J (April 2008). "PCA3: a molecular urine assay for predicting prostate biopsy outcome". The Journal of Urology. 179 (4): 1587–92. doi:10.1016/j.juro.2007.11.038. PMID 18295257.
  9. ^ a b Haese A, de la Taille A, van Poppel H, Marberger M, Stenzl A, Mulders PF, Huland H, Abbou CC, Remzi M, Tinzl M, Feyerabend S, Stillebroer AB, van Gils MP, Schalken JA (November 2008). "Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy". European Urology. 54 (5): 1081–8. doi:10.1016/j.eururo.2008.06.071. PMID 18602209.
  10. ^ Marks LS, Fradet Y, Deras IL, Blase A, Mathis J, Aubin SM, Cancio AT, Desaulniers M, Ellis WJ, Rittenhouse H, Groskopf J (March 2007). "PCA3 molecular urine assay for prostate cancer in men undergoing repeat biopsy". Urology. 69 (3): 532–5. doi:10.1016/j.urology.2006.12.014. PMID 17382159.
  11. ^ de la Taille A (September 2007). "Progensa PCA3 test for prostate cancer detection". Expert Review of Molecular Diagnostics. 7 (5): 491–7. doi:10.1586/14737159.7.5.491. PMID 17892357. S2CID 11338727.
  12. ^ Nakanishi H, Groskopf J, Fritsche HA, Bhadkamkar V, Blase A, Kumar SV, Davis JW, Troncoso P, Rittenhouse H, Babaian RJ (May 2008). "PCA3 molecular urine assay correlates with prostate cancer tumor volume: implication in selecting candidates for active surveillance". The Journal of Urology. 179 (5): 1804–9, discussion 1809–10. doi:10.1016/j.juro.2008.01.013. PMID 18353398.
  13. ^ van Gils MP, Hessels D, Hulsbergen-van de Kaa CA, Witjes JA, Jansen CF, Mulders PF, Rittenhouse HG, Schalken JA (August 2008). "Detailed analysis of histopathological parameters in radical prostatectomy specimens and PCA3 urine test results". The Prostate. 68 (11): 1215–22. doi:10.1002/pros.20781. PMID 18500693. S2CID 38697285.
  14. ^ Whitman EJ, Groskopf J, Ali A, Chen Y, Blase A, Furusato B, Petrovics G, Ibrahim M, Elsamanoudi S, Cullen J, Sesterhenn IA, Brassell S, Rittenhouse H, Srivastava S, McLeod DG (November 2008). "PCA3 score before radical prostatectomy predicts extracapsular extension and tumor volume". The Journal of Urology. 180 (5): 1975–8, discussion 1978–9. doi:10.1016/j.juro.2008.07.060. PMID 18801539.
  15. ^ Soyoung Kim and Anand Basu (30 April 2012). "Hologic to buy Gen-Probe for $3.75 billion". Reuters. Retrieved April 8, 2017.

추가 읽기

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  • Day JR, Jost M, Reynolds MA, Groskopf J, Rittenhouse H (February 2011). "PCA3: from basic molecular science to the clinical lab". Cancer Letters. 301 (1): 1–6. doi:10.1016/j.canlet.2010.10.019. PMID 21093148.
  • Schalken JA, Hessels D, Verhaegh G (November 2003). "New targets for therapy in prostate cancer: differential display code 3 (DD3(PCA3)), a highly prostate cancer-specific gene". Urology. 62 (5 Suppl 1): 34–43. doi:10.1016/S0090-4295(03)00759-3. PMID 14607216.
  • Ankerst DP, Groskopf J, Day JR, Blase A, Rittenhouse H, Pollock BH, Tangen C, Parekh D, Leach RJ, Thompson I (October 2008). "Predicting prostate cancer risk through incorporation of prostate cancer gene 3". The Journal of Urology. 180 (4): 1303–8, discussion 1308. doi:10.1016/j.juro.2008.06.038. PMID 18707724.
  • Roobol MJ, Schröder FH, van Leeuwen P, Wolters T, van den Bergh RC, van Leenders GJ, Hessels D (October 2010). "Performance of the prostate cancer antigen 3 (PCA3) gene and prostate-specific antigen in prescreened men: exploring the value of PCA3 for a first-line diagnostic test". European Urology. 58 (4): 475–81. doi:10.1016/j.eururo.2010.06.039. PMID 20637539.
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  • Haese A, de la Taille A, van Poppel H, Marberger M, Stenzl A, Mulders PF, Huland H, Abbou CC, Remzi M, Tinzl M, Feyerabend S, Stillebroer AB, van Gils MP, Schalken JA (November 2008). "Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy". European Urology. 54 (5): 1081–8. doi:10.1016/j.eururo.2008.06.071. PMID 18602209.
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