RING 핑거 단백질 83 (RNF83)이라고도 알려진 TNF 수용체 관련 인자 4 (TRAF4)는 인간에서 TRAF4 유전자 에 의해 인코딩되는 단백질 이다.[5] [6] [7]
TRAF4는 비계 단백질 계열인 TNF 수용체 관련 인자(TRAF) 계열의 일원이다.[8] TRAF 단백질은 IL-1R /Toll 수용체와 TNF 수용체를 NF-κB 와 미토겐 활성 단백질 키나제 활성화로 이어지는 신호 요인과 연결한다. 그러나 TRAF4는 TNF 수용체와 상호작용하는 것으로 알려져 있지 않고 세포 기능도 잘 파악되지 않는다.[9]
단백질 상호작용 TRAF4는 신경트로핀 수용체 p75 ([10] [11] 이 단백질은 NAD(P)H 산화효소 로 알려진 다단백질 복합체에 포함된 세포독성 규제 인자인 p47pox 에 결합하는 것으로 밝혀졌다. 따라서 이 단백질은 MAPK8 /JNK의 산화 활성화에 관여하는 것으로 생각된다. 또는 분할된 대본 변형이 관찰되었지만 단 하나의 전체 길이 특성이 결정되었다.[7]
최근 보고서에 따르면 TRAF4는 NOD-Like 수용체 NOD1과 NOD2에 바인딩되며, 특히 활성화된 NOD2-RIP2 복합체에 의한 NF-164B 의 활성화를 억제한다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000076604 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000017386 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Dec 1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma" . J Biol Chem . 270 (43): 25715–21. doi :10.1074/jbc.270.43.25715 PMID 7592751 . ^ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics . 28 (3): 367–76. doi :10.1006/geno.1995.1163 . PMID 7490069 . ^ a b "Entrez Gene: TRAF4 TNF receptor-associated factor 4" .^ Wajant H, Henkler F, Scheurich P (June 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal . 13 (6): 389–400. doi :10.1016/S0898-6568(01)00160-7 . PMID 11384837 . ^ Kedinger V, Rio MC (2007). "TRAF4, the unique family member". Adv. Exp. Med. Biol . Advances in Experimental Medicine and Biology. 597 : 60–71. doi :10.1007/978-0-387-70630-6_5 . ISBN 978-0-387-70629-0 PMID 17633017 . ^ Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (October 1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction" . J. Biol. Chem . 274 (42): 30202–8. doi :10.1074/jbc.274.42.30202 PMID 10514511 . ^ Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC (June 1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues" . Am. J. Pathol . 152 (6): 1549–61. PMC 1858434 PMID 9626059 . ^ Marinis JM, Homer CR, McDonald C, Abbott DW (2011). "A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses" . J. Biol. Chem . 286 (3): 1938–1950. doi :10.1074/jbc.M110.189308 PMC 3023490 PMID 21097508 .
추가 읽기 Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)" . Oncogene . 20 (44): 6482–91. doi :10.1038/sj.onc.1204788 PMID 11607847 . Masson R, Régnier CH, Chenard MP, et al. (1998). "Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development" . Mech. Dev . 71 (1–2): 187–91. doi :10.1016/S0925-4773(97)00192-5 PMID 9507120 . S2CID 13877166 . Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains" . J. Biol. Chem . 276 (26): 24242–52. doi :10.1074/jbc.M100354200 PMID 11279055 . Régnier CH, Masson R, Kedinger V, et al. (2002). "Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice" . Proc. Natl. Acad. Sci. U.S.A . 99 (8): 5585–90. doi :10.1073/pnas.052124799 PMC 122813 PMID 11943846 . Xu YC, Wu RF, Gu Y, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase" . J. Biol. Chem . 277 (31): 28051–7. doi :10.1074/jbc.M202665200 PMID 12023963 . Glauner H, Siegmund D, Motejadded H, et al. (2002). "Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4)" . Eur. J. Biochem . 269 (19): 4819–29. doi :10.1046/j.1432-1033.2002.03180.x PMID 12354113 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Sax JK, El-Deiry WS (2003). "Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene" . J. Biol. Chem . 278 (38): 36435–44. doi :10.1074/jbc.M303191200 PMID 12788948 . Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H (2003). "Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase". Leuk. Res . 27 (8): 687–94. doi :10.1016/S0145-2126(02)00325-9 . PMID 12801526 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ma BY, Mikolajczak SA, Danesh A, et al. (2005). "The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells" . Blood . 106 (6): 2002–10. doi :10.1182/blood-2004-04-1622 PMID 15941918 . Takeshita F, Ishii KJ, Kobiyama K, et al. (2005). "TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF" . Eur. J. Immunol . 35 (8): 2477–85. doi :10.1002/eji.200526151 PMID 16052631 . S2CID 560536 . Abell AN, Johnson GL (2006). "MEKK4 is an effector of the embryonic TRAF4 for JNK activation" . J. Biol. Chem . 280 (43): 35793–6. doi :10.1074/jbc.C500260200 PMID 16157600 .
케모킨 CSF
인터페론
IFNAR(α/β, I) 고민자: 알빈터페론 인터페론 알파(인터페론 알파, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )인터페론 알파 2a 인터페론 알파 2b 인터페론 알파 n1 인터페론 알파콘-1 인터페론 알파-n3 인터페론 베타(IFN-β)( IFNB1 , IFNB3 )인터페론 베타 1a 인터페론 베타 1b 인터페론 카파(IFN-filename/changes/changes/changes, IFNK) 인터페론 오메가(IFN-Ω, IFNW1) 페긴터페론 알파-2a 페긴터페론 알파-2b IFNGR (1998, II) IFNLR (1998, III) 대신 여기 서 IL-28R(IFNLR)을 참조하십시오.
인터루킨 TGFβ TNF 다른이들