VIPR1

VIPR1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1OF2, 1OGT, 3B3I, 3B6S, 3DTX, 3HCV, 5DEF, 5DEG
식별자
별칭	VIPR1, HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R, vasoactive intestinal peptide receptor 1
외부 ID	OMIM: 192321 MGI: 109272 HomoloGene: 3399 GeneCard: VIPR1
유전자 위치(인간)
쳇.	3번 염색체(인간)
끝	42,537,573 bp
유전자 위치(마우스)
쳇.	9번 염색체(쥐)
끝	121,672,954bp
RNA 표현 패턴
	표현된 상단
	오른쪽 폐; ; 좌측 폐 상부엽; ; 폐상엽; ; 폐를 끼치다; ; 십이지장; ; 횡결장; ; 소장; ; 직장의;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	투과 브레인 신호 수용체 활성; 신호 변환기 활동; G 단백질 결합 수용체 활성; GO:0001948 단백질 결합; 혈관활성 장내 폴리펩타이드 수용체 활성; 펩타이드 호르몬 결합; G 단백질 결합 펩타이드 수용체 활성;
셀룰러 컴포넌트	플라즈마 막; 막으로 막다; 막의 적분 성분; 수용체 복합체; 플라스마 막의 적분 성분;
생물학적 과정	세포표면 수용체 신호 경로; 세포 인구 증식에 대한 긍정적인 규제; G 단백질 결합 수용체 신호 경로; 신호 전달; G 단백질 결합 수용체 신호 경로, 주기적 뉴클레오티드 두 번째 메신저와 결합;
	출처:아미고 / 퀵고
직교체
	7433
	22354
	ENSG00000114812
	ENSMUSG00000032528
	P32241
	P97751
	NM_001251882; NM_001251883; NM_001251884; NM_001251885; NM_004624
	NM_011703
	NP_001238811; NP_001238812; NP_001238813; NP_001238814; NP_004615
	NP_035833
	위키다타
인간 보기/편집	마우스 보기/편집

VPAC라고도₁ 알려진 Vasoactive 장내 폴리펩타이드 수용체 1은 단백질로, 인간에서 VIPR1 유전자에 의해 인코딩된다.^[5]VPAC는₁ 뇌(뇌피질, 해마, 편도), 폐, 전립선, 말초혈구 백혈구, 간, 소장, 심장, 비장, 태반, 신장, 흉선, 고환)에서 발현된다.^[6]^[7]^[8]null

함수

VPAC는₁ 작은 신경펩타이드인 VIP의 수용체다.Vasoactive 장 펩타이드는 원활한 근육 이완, 외분비 및 내분비 분비, 폐와 장 상피에 물과 이온 유속이 관여한다.그것의 작용은 아데닐레이트 사이클라아제를 활성화하는 구아닌 뉴클레오티드 결합 단백질과 연관된 적분막 수용체를 통해 작용한다.^[5]null

VIP는 VPAC1을₁ 통해 자동분비 방식으로 작용하여 메가카리세포 증식을 억제하고 프롤레트 형성을 유도한다.^[9]^[10]null

임상적 유의성

특발성 아칼라시아 환자는 VIPR1에 영향을 미치는 SNP의 분포에 상당한 차이를 보인다.^[11]

VIP와 PACAP 수치는 스트레스 요실금 및 골반 장기 탈구 환자의 전방 질 벽에서 감소되었으며, 이러한 질병의 병태학에 참여할 수 있다.^[12]null

참고 항목

바소액티브 장 펩타이드 수용체

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000114812 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000032528 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1".
^ Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (Apr 1992). "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide". Neuron. 8 (4): 811–9. doi:10.1016/0896-6273(92)90101-I. PMID 1314625. S2CID 43589458.
^ Usdin TB, Bonner TI, Mezey E (Dec 1994). "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions". Endocrinology. 135 (6): 2662–80. doi:10.1210/en.135.6.2662. PMID 7988457.
^ Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. Bibcode:1995PNAS...92.2939S. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.
^ Nam C, Case AJ, Hostager BS, O'Dorisio MS (Feb 2009). "The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation". Journal of Molecular Neuroscience. 37 (2): 160–7. doi:10.1007/s12031-008-9119-x. PMID 18663606. S2CID 2030939.
^ Freson K, Peeters K, De Vos R, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C (Feb 2008). "PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications". Blood. 111 (4): 1885–93. doi:10.1182/blood-2007-06-098558. PMID 18000164.
^ Paladini F, Cocco E, Cascino I, Belfiore F, Badiali D, Piretta L, Alghisi F, Anzini F, Fiorillo MT, Corazziari E, Sorrentino R (Jun 2009). "Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene". Neurogastroenterology and Motility. 21 (6): 597–602. doi:10.1111/j.1365-2982.2009.01284.x. PMID 19309439. S2CID 24081228.
^ Hong X, Huang L, Song Y (Aug 2008). "Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse". International Urogynecology Journal and Pelvic Floor Dysfunction. 19 (8): 1151–7. doi:10.1007/s00192-008-0585-z. PMID 18351280. S2CID 2482642.

추가 읽기

"[Quaternary structure of rabbit skeletal muscle glycogen synthetase]" [Quaternary structure of rabbit skeletal muscle glycogen synthetase]. Doklady Akademii Nauk SSSR. 222 (4): 997–1000. Jun 1975. PMID 807467.
Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. Bibcode:1995PNAS...92.2939S. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.
Couvineau A, Gaudin P, Maoret JJ, Rouyer-Fessard C, Nicole P, Laburthe M (Jan 1995). "Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP". Biochemical and Biophysical Research Communications. 206 (1): 246–52. doi:10.1006/bbrc.1995.1034. PMID 7818527.
Gagnon AW, Aiyar N, Elshourbagy NA (Mar 1994). "Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor". Cellular Signalling. 6 (3): 321–33. doi:10.1016/0898-6568(94)90037-X. PMID 7917790.
Sreedharan SP, Patel DR, Xia M, Ichikawa S, Goetzl EJ (Aug 1994). "Human vasoactive intestinal peptide1 receptors expressed by stable transfectants couple to two distinct signaling pathways". Biochemical and Biophysical Research Communications. 203 (1): 141–8. doi:10.1006/bbrc.1994.2160. PMID 8074647.
Couvineau A, Rouyer-Fessard C, Darmoul D, Maoret JJ, Carrero I, Ogier-Denis E, Laburthe M (Apr 1994). "Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains". Biochemical and Biophysical Research Communications. 200 (2): 769–76. doi:10.1006/bbrc.1994.1517. PMID 8179610.
Moody TW, Zia F, Draoui M, Brenneman DE, Fridkin M, Davidson A, Gozes I (May 1993). "A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth". Proceedings of the National Academy of Sciences of the United States of America. 90 (10): 4345–9. Bibcode:1993PNAS...90.4345M. doi:10.1073/pnas.90.10.4345. PMC 46507. PMID 8389448.
Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (Jun 1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochemical and Biophysical Research Communications. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
Couvineau A, Fabre C, Gaudin P, Maoret JJ, Laburthe M (Feb 1996). "Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane". Biochemistry. 35 (6): 1745–52. doi:10.1021/bi952022h. PMID 8639654.
Pozo D, Guerrero JM, Segura JJ, Calvo JR (Sep 1996). "Thymosin alpha 1 interacts with the VIP receptor-effector system in rat and mouse immunocompetent cells". Immunopharmacology. 34 (2–3): 113–23. doi:10.1016/0162-3109(96)00131-2. PMID 8886855.
Couvineau A, Maoret JJ, Rouyer-Fessard C, Carrero I, Laburthe M (Dec 1998). "Cloning and functional characterization of the human VIP1/PACAP receptor promoter". Annals of the New York Academy of Sciences. 865 (1): 59–63. Bibcode:1998NYASA.865...59C. doi:10.1111/j.1749-6632.1998.tb11163.x. PMID 9927997. S2CID 46520267.
Knudsen SM, Tams JW, Wulff BS, Fahrenkrug J (Dec 1998). "Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production". Annals of the New York Academy of Sciences. 865 (1): 259–65. Bibcode:1998NYASA.865..259K. doi:10.1111/j.1749-6632.1998.tb11186.x. PMID 9928020. S2CID 27000806.
Marie J, Wakkach A, Coudray A, Chastre E, Berrih-Aknin S, Gespach C (Feb 1999). "Functional expression of receptors for calcitonin gene-related peptide, calcitonin, and vasoactive intestinal peptide in the human thymus and thymomas from myasthenia gravis patients". Journal of Immunology. 162 (4): 2103–12. PMID 9973484.
Mimuro H, Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (Sep 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". The Journal of Biological Chemistry. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.
Nicole P, Maoret JJ, Couvineau A, Momany FA, Laburthe M (Sep 2000). "Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding". Biochemical and Biophysical Research Communications. 276 (2): 654–9. doi:10.1006/bbrc.2000.3375. PMID 11027527.
Bajo AM, Juarranz MG, Valenzuela P, Martínez P, Prieto JC, Guijarro LG (Sep 2000). "Expression of vasoactive intestinal peptide (VIP) receptors in human uterus". Peptides. 21 (9): 1383–8. doi:10.1016/S0196-9781(00)00282-5. PMID 11072126. S2CID 429907.
Lara-Marquez M, O'Dorisio M, O'Dorisio T, Shah M, Karacay B (Feb 2001). "Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells". Journal of Immunology. 166 (4): 2522–30. doi:10.4049/jimmunol.166.4.2522. PMID 11160313.
Martin Shreeve S (Feb 2002). "Identification of G-proteins coupling to the vasoactive intestinal peptide receptor VPAC(1) using immunoaffinity chromatography: evidence for precoupling". Biochemical and Biophysical Research Communications. 290 (4): 1300–7. doi:10.1006/bbrc.2002.6342. PMID 11812005.
Dorsam G, Goetzl EJ (Apr 2002). "Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros". The Journal of Biological Chemistry. 277 (16): 13488–93. doi:10.1074/jbc.M107922200. PMID 11812772.
Branch DR, Valenta LJ, Yousefi S, Sakac D, Singla R, Bali M, Sahai BM, Ma XZ (Feb 2002). "VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection". AIDS. 16 (3): 309–19. doi:10.1097/00002030-200202150-00001. PMID 11834941. S2CID 25584856.

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000114812 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000032528 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1".

[Ishihara,_1992-6] Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (Apr 1992). "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide". Neuron. 8 (4): 811–9. doi:10.1016/0896-6273(92)90101-I. PMID 1314625. S2CID 43589458.

[Usdin,_1994-7] Usdin TB, Bonner TI, Mezey E (Dec 1994). "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions". Endocrinology. 135 (6): 2662–80. doi:10.1210/en.135.6.2662. PMID 7988457.

[Sreedharan,_1995-8] Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. Bibcode:1995PNAS...92.2939S. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.

[9] Nam C, Case AJ, Hostager BS, O'Dorisio MS (Feb 2009). "The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation". Journal of Molecular Neuroscience. 37 (2): 160–7. doi:10.1007/s12031-008-9119-x. PMID 18663606. S2CID 2030939.

[10] Freson K, Peeters K, De Vos R, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C (Feb 2008). "PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications". Blood. 111 (4): 1885–93. doi:10.1182/blood-2007-06-098558. PMID 18000164.

[Paladini-2009-11] Paladini F, Cocco E, Cascino I, Belfiore F, Badiali D, Piretta L, Alghisi F, Anzini F, Fiorillo MT, Corazziari E, Sorrentino R (Jun 2009). "Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene". Neurogastroenterology and Motility. 21 (6): 597–602. doi:10.1111/j.1365-2982.2009.01284.x. PMID 19309439. S2CID 24081228.

[Hong-2008-12] Hong X, Huang L, Song Y (Aug 2008). "Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse". International Urogynecology Journal and Pelvic Floor Dysfunction. 19 (8): 1151–7. doi:10.1007/s00192-008-0585-z. PMID 18351280. S2CID 2482642.

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VIPR1

네임스페이스

더

목차

함수

임상적 유의성

참고 항목

참조

추가 읽기