ACSS3

ACSS3
Identifikatori
Aliasi	ACSS3
Vanjski ID-jevi	OMIM: 614356 MGI: 2685720 HomoloGene: 11587 GeneCards: ACSS3
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	81,261,210 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	106,959,529 bp
Ontologija gena
Molekularna funkcija	• nucleotide binding; • ligase activity; • catalytic activity; • ATP binding; • acetate-CoA ligase activity;
Ćelijska komponenta	• mitohondrija; • mitochondrial matrix;
Biološki proces	• metabolizam; • ketone body biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	79611
	380660
	ENSG00000111058
	ENSMUSG00000035948
	Q9H6R3
	Q14DH7
	NM_024560; NM_001330242; NM_001330243
	NM_001142804; NM_198636
	NP_001317171; NP_001317172; NP_078836
	NP_001136276; NP_941038
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 3 porodice kratkolančanih acil-CoA sintetaza je protein koji je kod ljudi kodiran genom ACSS3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 686 aminokiselina, a molekulska težina 74.778 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKPSWLQCRK	VTSAGGLGGP	LPGSSPARGA	GAALRALVVP	GPRGGLGGRG
CRALSSGSGS	EYKTHFAASV	TDPERFWGKA	AEQISWYKPW	TKTLENKHSP
STRWFVEGML	NICYNAVDRH	IENGKGDKIA	IIYDSPVTNT	KATFTYKEVL
EQVSKLAGVL	VKHGIKKGDT	VVIYMPMIPQ	AMYTMLACAR	IGAIHSLIFG
GFASKELSSR	IDHVKPKVVV	TASFGIEPGR	RVEYVPLVEE	ALKIGQHKPD
KILIYNRPNM	EAVPLAPGRD	LDWDEEMAKA	QSHDCVPVLS	EHPLYILYTS
GTTGLPKGVI	RPTGGYAVML	HWSMSSIYGL	QPGEVWWAAS	DLGWVVGHSY
ICYGPLLHGN	TTVLYEGKPV	GTPDAGAYFR	VLAEHGVAAL	FTAPTAIRAI
RQQDPGAALG	KQYSLTRFKT	LFVAGERCDV	ETLEWSKNVF	RVPVLDHWWQ
TETGSPITAS	CVGLGNSKTP	PPGQAGKSVP	GYNVMILDDN	MQKLKARCLG
NIVVKLPLPP	GAFSGLWKNQ	EAFKHLYFEK	FPGYYDTMDA	GYMDEEGYLY
VMSRVDDVIN	VAGHRISAGA	IEESILSHGT	VADCAVVGKE	DPLKGHVPLA
LCVLRKDINA	TEEQVLEEIV	KHVRQNIGPV	AAFRNAVFVK	QLPKTRSGKI
PRSALSAIVN	GKPYKITSTI	EDPSIFGHVE	EMLKQA

Funkcija

ACSS3 je dio porodice poznate kao acil-koenzim A sintetaze (ACS), koje kataliziraju početnu reakciju u metabolizmu masnih kiselina. Ova reakcija aktivira masne kiseline tioesterifikacijom do CoA, omogućavajući im tako učešće u anaboličkim i kataboličkim putevima. Postojanje mnogih ACS-ova sugerira da svaki ima jedinstvenu ulogu, usmjeravajući acil-CoA proizvod na određenu metaboličku sudbinu. Poznavanje potpunog kompleksa ACS gena u ljudskom genomu olakšat će buduća istraživanja za karakteriziranje njihovih specifičnih bioloških funkcija.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111058 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035948 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".
^ "UniProt, Q9H6R3". Pristupljeno 6. 8. 2021.
^ Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Dopunska literatura

Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP (Sep 2013). "A genome-wide association study of a sustained pattern of antidepressant response". Journal of Psychiatric Research. 47 (9): 1157–65. doi:10.1016/j.jpsychires.2013.05.002. PMC 3710535. PMID 23726668.
Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Portal Biologija

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111058 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035948 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".

[UniProt-6] "UniProt, Q9H6R3". Pristupljeno 6. 8. 2021.

[7] Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

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p r u Enzimi: CO CS i CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanin Arginin Asparagin Aspartat Cysteine D-alanine—poly(phosphoribitol) ligase Glutamat Glutamin Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak