STK35L1

STK35L1
Identifikatori
Aliasi	STK35
Vanjski ID-jevi	OMIM: 609370 MGI: 1914583 HomoloGene: 15441 GeneCards: STK35
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	2,177,038 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	129,674,207 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • nucleotide binding; • protein kinase activity; • protein serine/threonine kinase activity; • ATP binding; • kinase activity;
Ćelijska komponenta	• citoplazma; • Jedarce; • jedro; • nuclear body;
Biološki proces	• protein phosphorylation; • Fosforilacija; • GO:0007126 Mejoza;
	Izvori:Amigo / QuickGO
Ortolozi
	140901
	67333
	ENSG00000125834
	ENSMUSG00000037885
	Q8TDR2
	Q80ZW0
	NM_080836
	NM_001038635; NM_183262
	NP_543026
	NP_001033724; NP_899085
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

STK35L1 je protein koji je kod ljudi kodiran genom humans is encoded by the STK35 (serin/treonin-kinaza 35).^[5] Član je porodice NKF4 (Nova kinazna porodica 4) Ser/Thr kinaza (STK) i kod ljudi svrstan u grupu "ostali" Kinases, Kinomes and Evolution, at Kinase.Com.

Prije toga, STK35L1 je imenovan kao Clik1 (CLP36 interaktivna kinaza 1) na osnovu studije koja je pokazala povezanost STK35 sa CLP36, nakon prekomjerne ekspresije oba proteina u osteosarkomskim ćelijama.^[6]^[7] Gen Clik1 kojeg su opisali Vallenius et al. kodira protein od 501 aminokiselina. Kasnije su Goyal et al. otkrili da kodirajuća sekvenca gena STK35 nije potpuna. Novootkrivena sekvenca gena STK35 kodira protein od 534 aminokiseline sa N-terminalnim izduženjem od 133 aminokiseline. Označen je kao STK35L1.

Funkcije

STK35L1 se pretežno nalazi u jedrui i jedarcetu. Jedarni aktin identificiran je kao novi vezujući partner STK35L1.^[8] Međutim, može stupiti u interakciju s PDLIM1 / CLP-36 u citoplazmi i lokalizirati se u vlakna aktinskog stresa. STK35L1 regulira ekspresiju CDKN2A i inhibira prelazak G1- u S-fazu. Osiromašenjem STK35L1 siRNK oštećenim endotelom, migracija ćelija STK35L1 može djelovati kao centralna kinaza koja povezuje ćelijski ciklus i migraciju endotelnih ćelija.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MGHQESPLAR	APAGGAAYVK	RLCKGLSWRE	HVESHGSLGA	QASPASAAAA
EGSATRRARA	ATSRAARSRR	QPGPGADHPQ	AGAPGGKRAA	RKWRCAGQVT
IQGPAPPRPR	AGRRDEAGGA	RAAPLLLPPP	PAAMETGKDG	ARRGTQSPER
KRRSPVPRAP	STKLRPAAAA	RAMDPVAAEA	PGEAFLARRR	PEGGGGSARP
RYSLLAEIGR	GSYGVVYEAV	AGRSGARVAV	KKIRCDAPEN	VELALAEFWA
LTSLKRRHQN	VVQFEECVLQ	RNGLAQRMSH	GNKSSQLYLR	LVETSLKGER
ILGYAEEPCY	LWFVMEFCEG	GDLNQYVLSR	RPDPATNKSF	MLQLTSAIAF
LHKNHIVHRD	LKPDNILITE	RSGTPILKVA	DFGLSKVCAG	LAPRGKEGNQ
DNKNVNVNKY	WLSSACGSDF	YMAPEVWEGH	YTAKADIFAL	GIIIWAMIER
ITFIDSETKK	ELLGTYIKQG	TEIVPVGEAL	LENPKMELHI	PQKRRTSMSE
GIKQLLKDML	AANPQDRPDA	FELETRMDQV	TCAA

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125834 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037885 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Serine/threonine kinase 35". Pristupljeno 18. 2. 2012.
^ Vallenius T, Mäkelä TP (maj 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
^ Goyal P, Behring A, Kumar A, Siess W (16. 9. 2009). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
^ Goyal P, Behring A, Kumar A, Siess W (20. 1. 2011). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.

Dopunsdka literatura

Vallenius T, Mäkelä TP (maj 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
Goyal P, Behring A, Kumar A, Siess W (2009). Randau L (ured.). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
Goyal P, Behring A, Kumar A, Siess W (2011). Parise G (ured.). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125834 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037885 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Serine/threonine kinase 35". Pristupljeno 18. 2. 2012.

[6] Vallenius T, Mäkelä TP (maj 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.

[7] Goyal P, Behring A, Kumar A, Siess W (16. 9. 2009). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.

[8] Goyal P, Behring A, Kumar A, Siess W (20. 1. 2011). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.

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