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Insertion or duplication that includes a stop codon #829

@b0d0nne11

Description

@b0d0nne11

This variant is an insertion of 12 bp where the second inserted codon is a stop codon.

In [1]: var_c = parse('NM_000159.4:c.1074_1075insAGTTGAAGGACC')

In [2]: var_p = am37.c_to_p(var_c)

In [3]: str(var_p)
Out[3]: 'NP_000150.1:p.(Asp358_Gln359insSerTerArgThr)'

We believe this should result in NP_000150.1:p.(Asp358_Gln359insSerTer).

This variant is identical to the above example except that it's missing the last bp.

In [4]: var_c = parse('NM_000159.4:c.1074_1075insAGTTGAAGGAC')

In [5]: var_p = am37.c_to_p(var_c)

In [6]: str(var_p)
Out[6]: 'NP_000150.1:p.(Gln359SerfsTer2)'

This shouldn't functionally change the result since the difference occurs after the newly added stop codon so the result should still be NP_000150.1:p.(Asp358_Gln359insSerTer).

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