I've been going through the calculations and trying to verify your numbers. In this issue I am sharing my findings.
Coefficients
They match the paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/pdf/aging-10-101414.pdf
Unit Conversions
Verified:
Issues:
CRP
It seems you are using a molar mass of 105,000 g/mol for C-Reactive Protein (CRP), which would give 95.2381 nmol/L for 1 mg/dL. However, most sources reference a molar mass closer to 115,000 g/mol for CRP, leading to a conversion of 86.96 nmol/L.
This 115,000 g/mol figure is widely used (e.g., Wikipedia) and considers CRP’s pentameric structure. You might want to double-check if this higher molar mass could apply here, as it may bring your result in line with common references.
Lymphocytes
Probably no issue here, just a minor complication that probably needs not be addressed. It seems you’re using 1% lymphocytes = 1,000 cells/μL (or 1 x 10⁹ cells/L), which is correct if you’re assuming a standard WBC count. This approach works well for estimation, but double-checking against the actual WBC count could ensure accuracy if available.
I've been going through the calculations and trying to verify your numbers. In this issue I am sharing my findings.
Coefficients
They match the paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC5940111/pdf/aging-10-101414.pdf
Unit Conversions
Verified:
Issues:
CRP
It seems you are using a molar mass of 105,000 g/mol for C-Reactive Protein (CRP), which would give 95.2381 nmol/L for 1 mg/dL. However, most sources reference a molar mass closer to 115,000 g/mol for CRP, leading to a conversion of 86.96 nmol/L.
This 115,000 g/mol figure is widely used (e.g., Wikipedia) and considers CRP’s pentameric structure. You might want to double-check if this higher molar mass could apply here, as it may bring your result in line with common references.
Lymphocytes
Probably no issue here, just a minor complication that probably needs not be addressed. It seems you’re using 1% lymphocytes = 1,000 cells/μL (or 1 x 10⁹ cells/L), which is correct if you’re assuming a standard WBC count. This approach works well for estimation, but double-checking against the actual WBC count could ensure accuracy if available.