The super(CefApp, self).__init__(redirect=redirect) call never returns and OnInit is never called. This only occurs if cef.Initialize() was called beforehand. There seem to be two solutions:

1. Initialize CEF after wx was initialized, eg. during a call to embed_browser(). However that results with autorelease error when exiting app.

2. Implement CefApp.OnPreInit and do wx window creation in that event instead of OnInit.

Issue originally reported on the Forum:
https://groups.google.com/d/topic/cefpython/tM8SXp_a_u0/discussion