Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: genetics

When RNA molecules are synthesized by cells—a critical process in the creation of proteins and other cellular functions—they typically undergo a series of “folding” events that determine their structure and the role they will play in expressing genetic information in living organisms.

Until recently, however, not much was known about these folding processes that occur very early in the life of RNA molecules.

But Yale researchers have now developed a method to map and measure the structure of RNA as it develops, an advance that may help scientists design more effective treatments for a host of diseases. Their findings are described in the journal Molecular Cell.

Read more | >

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Is NAD Associated With Biomarkers Of Mitochondrial Function?” | >

Ribonucleic acid (RNA) molecules may be best known for their job ferrying the genetic information encoded in DNA to a cell’s protein factories, but these molecules aren’t just a middleman for protein production. In fact, some RNA molecules don’t code for proteins at all and serve various other important functions in cells, such as regulating gene expression and catalyzing chemical reactions. However, the functions of many non-coding RNAs remain mysterious.

Read more | >

In research published in New Phytologist, investigators reveal that tomato ripening is regulated by the same mechanism that contributes to humans’ and animals’ life-and health spans.

The mechanism, called autophagy, regulates cellular recycling and operates in all lifeforms apart from bacteria. This latest work shows that autophagy affects tomato fruit ripening by controlling the production of ethylene. Ethylene is the primary hormone that controls ripening in many fruits such as apples, bananas, mangoes, avocados, and tomatoes.

To assess the role of autophagy in ripening, the team of researchers from the Volcani Institute, in Israel, and the University of Tübingen, in Germany, generated tomato plants that allow a temporal genetic repression of autophagy, specifically in mature non-ripe fruits.

Read more | >

/CNW/ — Biogen Canada Inc. announced today that Health Canada has issued marketing authorization with conditions (Notice of Compliance with Conditions (NOC/c))…

Read more | >

Birmingham scientists have identified an essential genetic code for a method called plasmid curing, which aims to “displace” antibiotic-resistance genes from bacteria.

Plasmids, which are small, circular strands of DNA, play a crucial role in allowing to share beneficial genes rapidly in a changing environment, most concerningly when they carry genes conferring resistance to antibiotics.

Professor Chris Thomas from Birmingham’s School of Biosciences has investigated plasmid curing for many years, and engineered useful “multi-copy” (many copies in each bacterium) plasmids for this purpose, resulting in a patented, efficient way to displace unwanted plasmids that carry resistance.

Read more | >

A new butterfly species, Satyrium curiosolus, has been discovered in Alberta. Isolated for millennia, it shows unique traits and faces conservation risks due to low genetic diversity. In Canada’s Rocky Mountains, a modest yet remarkable butterfly has gone largely unnoticed by science for years. W

Read more | >

Urban rats spread a deadly bacteria as they migrate within cities that can be the source of a potentially life-threatening disease in humans, according to a six-year study by Tufts University researchers and their collaborators that also discovered a novel technique for testing rat kidneys.

Leptospirosis is a disease caused by a type of bacteria often found in rats. It’s spread through their urine into soil, water, or elsewhere in the environment, where it becomes a source of infection and contamination for humans, dogs, and other species. While it’s prevalent worldwide, it’s more common in tropical regions, though a changing climate means it could become more common in colder regions as they warm.

In Boston, leptospirosis persists in local rat populations, and different strains of the bacteria move around the city as groups of rats migrate, according to a new study by Marieke Rosenbaum, M.P.H., D.V.M., assistant professor in the Department of Infectious Disease and Global Health at Cummings School of Veterinary Medicine at Tufts University, along with co-authors at Northern Arizona University (NAU), the United States Department of Agriculture (USDA), and the Centers for Disease Control and Prevention (CDC). In addition, their of a 2018 human leptospirosis case in Boston strongly suggests a link to rats as the source.

Read more | >

Myofibroblasts generate fibrotic scars after spinal cord injury (SCI). This is typically regarded as an impediment to nerve regeneration. Understanding the heterogeneous characteristics of fibrotic scars might help to develop strategies for remodeling fibrotic scars after SCI. However, the composition, origin and function of fibrotic scars have been a subject of ongoing debate in the field.

A recent study led by Profs. Dai Jianwu and Zhao Yannan from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences employed a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq) to demonstrate the heterogeneous distribution, source, and function of meningeal fibroblasts and perivascular fibroblasts in fibrotic scars.

Their research is published in the journal Nature Communications.

Read more | >