Amin N-metiltransferaza
| Amin N-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.49 | ||||||||
| CAS broj | 111694-10-1&title= 51377-47-0, 111694-10-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Amin N-metiltransferaza (EC 2.1.1.49, nikotinska N-metiltransferaza, triptaminska N-metiltransferaza, arilaminska N-metiltransferaza, triptaminska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:amin N-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + an amin S-adenozil-L-homocistein + metilisani amin
Ovaj enzim ima veoma široku specifičnost. Mnogi primarni, sekundarni i tercijarni amini mogu da deluju kao akceptori, uključujući triptamin, anilin, nikotin i mnoštvo lekova i drugih ksenobiotika.
- ↑ Ansher, S.S. and Jakoby, W.B. (1986). „Amine N-methyltransferases from rabbit liver”. J. Biol. Chem. 261: 3996-4001. PMID 3949799.
- ↑ Crooks, P.A., Godin, C.S., Damani, L.A., Ansher, S.S. and Jakoby, W.B. (1988). „Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases”. Biochem. Pharmacol. 37: 1673-1677. PMID 3377829.
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