Izomeraza
U biohemiji, izomeraza je enzim koji katalizuje strukturno preuređenje izomera. Izomeraze katalizuju reakcije oblika:
- A → B
gde je B izomer molekula A.
Imena izomeraza se formiraju kao „supstrat izomeraza“ (na primer, enoil CoA izomeraza), ili kao „supstrat tip izomeraze“ (na primer, fosfoglukomutaza).[1][2][3]
EC klasifikacija enzima grupiše izomeraze u klasu: EC 5. One se dele u šest potklasa:
- EC 5.1 obuhvata enzime koji katalizuju racemizaciju (racemaze) i epimerizaciju (epimeraze)
- EC 5.2 obuhvata enzime koji katalizuju izomerizaciju geometrijskih izomera (cis-trans izomeraze)
- EC 5.3 obuhvata intramolekularne oksidoreduktaze
- EC 5.4 obuhvata intramolekularne transferaze (mutaze)
- EC 5.5 obuhvata intramolekularne lijaze
- EC 5.99 obuhvata druge izomeraze (uključujući topoizomeraze)
- ↑ EC 5 Introduction from the Department of Chemistry at Queen Mary, University of London
- ↑ Isomerase - Dorland's Medical Dictionary for Health Consumers. 2007. Saunders, an imprint of Elsevier, Inc 6 Nov. 2009
- ↑ Isomerase - Webster's New World College Dictionary. LoveToKnow, n.d. Web. 6 November 2009.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.