Hijaluronan sintaza
| Hijaluronan sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.212 | ||||||||
| CAS broj | 39346-43-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hijaluronan sintaza (EC 2.4.1.212, spHAS, seHAS) je enzim sa sistematskim imenom Naizmenični UDP-alfa-N-acetil-D-glukozamin:beta-D-glukuronazil-(1->3)-(nascent hijaluronan) 4-N-acetil-beta-D-glukozaminiltransferaza i UDP-alfa-D-glukuronat:N-acetil-beta-D-glukozaminil-(1->4)-(nascentni hijaluronan) 3-beta-D-glukuronaziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) UDP-alfa-N-acetil-D-glukozamin + beta-D-glukuronazil-(1->3)-N-acetil-beta-D-glukozaminil-(1->4)-[nascentni hijaluronan] UDP + N-acetil-beta-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->3)-N-acetil-beta-D-glukozaminil-(1->4)-[nascentni hijaluronan]
- (2) UDP-alfa-D-glukuronat + N-acetil-beta-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->3)-[nascentni hijaluronan] UDP + beta-D-glukuronazil-(1->3)-N-acetil-beta-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->3)-[nascentni hijaluronan]
Za dejstvo enzima iz Streptococcus grupe A i grupe C je neophodan Mg2+.
- ↑ DeAngelis, P.L., Papaconstantinou, J. and Weigel, P.H. (1993). „Molecular cloning, identification and sequence of the hyaluronan synthase gene from Group A Streptococcus pyogenes”. J. Biol. Chem. 268: 19181-19184. PMID 8366070.
- ↑ Jing, W. and DeAngelis, P.L. (2000). „Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide”. Glycobiology 10: 883-889. PMID 10988250.
- ↑ DeAngelis, P.L. (1999). „Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase”. J. Biol. Chem. 274: 26557-26562. PMID 10473619.
- ↑ Tlapak-Simmons, V.L., Baron, C.A. and Weigel, P.H. (2004). „Characterization of the purified hyaluronan synthase from Streptococcus equisimilis”. Biochemistry 43: 9234-9242. PMID 15248781.
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