Timidilat sintaza (FAD)
| Timidilat sintaza (FAD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Timidilat sintaza (FAD) tetramer, Thermotoga maritima | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.1.148 | ||||||||
| CAS broj | 850167-13-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Timidilat sintaza (FAD) (EC 2.1.1.148, Thy1, ThyX) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat,FADH2:dUMP C-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5,10-metilintetrahidrofolat + dUMP + NADPH + H+ dTMP + tetrahidrofolat + NADP+
Ovaj enzim sadrži FAD.
- ↑ Myllykallio, H., Lipowski, G., Leduc, D., Filee, J., Forterre, P. and Liebl, U. (2002). „An alternative flavin-dependent mechanism for thymidylate synthesis”. Science 297: 105-107. PMID 12029065.
- ↑ Griffin, J., Roshick, C., Iliffe-Lee, E. and McClarty, G. (2005). „Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase”. J. Biol. Chem. 280: 5456-5467. PMID 15591067.
- ↑ Graziani, S., Bernauer, J., Skouloubris, S., Graille, M., Zhou, C.Z., Marchand, C., Decottignies, P., van Tilbeurgh, H., Myllykallio, H. and Liebl, U. (2006). „Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX”. J. Biol. Chem. 281: 24048-24057. PMID 16707489.
- ↑ Koehn, E.M., Fleischmann, T., Conrad, J.A., Palfey, B.A., Lesley, S.A., Mathews, I.I. and Kohen, A. (2009). „An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene”. Nature 458: 919-923. PMID 19370033.
- ↑ Koehn, E.M. and Kohen, A. (2010). „Flavin-dependent thymidylate synthase: a novel pathway towards thymine”. Arch. Biochem. Biophys. 493: 96-102. PMID 19643076.
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