VU-0238429

VU-0238429
IUPAC ime
	1-(4-metoksibenzil)-5-(trifluorometoksi)indol-2,3-dion
Identifikatori
PubChem	CID 42633508
ChemSpider	24606034
ChEMBL	CHEMBL466253
Hemijski podaci
Formula	C17H12F3NO4
Molarna masa	351,276 g/mol
	SMILES c2cc(OC)ccc2CN(C(=O)C1=O)c3ccc(cc13)OC(F)(F)F; ;
	InChI InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3 ; Key:CKLGZXFOLMHCMC-UHFFFAOYSA-N ;

VU-0238429 je lek koji deluje kao selektivni pozitivni alosterni modulator za muskarinski acetilholinski receptor M₅. On je bio prvi selektivni ligand razvijen za M₅ podtip.^[1] VU-0238429 je strukturni derivat raznije otkrivenih M₁-selektivnih pozitivnih alosternih modulatora poput VU-0119498.^[2]^[3]

Reference

^ Bridges TM; Marlo JE; Niswender CM; et al. (2009). „Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins”. Journal of Medicinal Chemistry. 52 (11): 3445—8. PMID 19438238. doi:10.1021/jm900286j.
^ Conn PJ, Jones CK, Lindsley CW (2009). „Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders”. Trends in Pharmacological Sciences. 30 (3): 148—55. PMC 2907736 . PMID 19201489. doi:10.1016/j.tips.2008.12.002.
^ M, Bridges T.., Kennedy J. P., Hopkins C. R., Conn P. J., Lindsley C. W. (2010). „Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators”. Bioorganic & Medicinal Chemistry Letters. 20 (19): 5617. doi:10.1016/j.bmcl.2010.08.042.

Spoljašnje veze

[pmid19438238-1] Bridges TM; Marlo JE; Niswender CM; et al. (2009). „Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins”. Journal of Medicinal Chemistry. 52 (11): 3445—8. PMID 19438238. doi:10.1021/jm900286j.

[pmid19201489-2] Conn PJ, Jones CK, Lindsley CW (2009). „Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders”. Trends in Pharmacological Sciences. 30 (3): 148—55. PMC 2907736 . PMID 19201489. doi:10.1016/j.tips.2008.12.002.

[3] M, Bridges T.., Kennedy J. P., Hopkins C. R., Conn P. J., Lindsley C. W. (2010). „Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators”. Bioorganic & Medicinal Chemistry Letters. 20 (19): 5617. doi:10.1016/j.bmcl.2010.08.042.

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