Charlie et ses drôles de dames se déchaînent

Bruce Willis, who is an advocate for adoption, has a cameo in the film. He asked Drew Barrymore, Cameron Diaz, and Lucy Liu for a favor for his cameo, that they do a PSA for adoption. They gladly did it.

The Thin Man seemed to have been killed in Charlie et ses drôles de dames (2000), but is back alive. McG has explained that this seemingly superhuman quality is the tongue-in-cheek mystique of this illogical, larger-than-life character.

After the "Columbia Pictures" intro, the shot zooms into the torch the woman is holding, starting the scene.

The US theatrical version was edited for violence and sex to avoid a R rating. This version was the basis for all international releases. For home video the film was released in its original theatrical version (North America only) and in a special "unrated" version (worldwide except UK). The unrated version contains a few more scenes of sex and violence, including an extended "Pussycat Dolls" dance number, some shots of characters lying still when dead or unconscious, and more graphic depections of some of the characters' demises. Also included in this version are two instance of characters spitting blood from their mouths during a fight and a reference to the first film. During the fight with the Irish mob on the freighter, Dylan puts her legs in the air while seated in an attempt to distract her attacker, similar to how she delayed a fight in the first film.

Featured in Wheel of Fortune: Wheel Goes to the Movies 1 (2003)