PHINMA UNIVERSITY OF PANGASINAN
COLLEGE OF HEALTH SCIENCES
                                                                      Nursing Department
                                                                      DRUG STUDY
                                                                      DRUG
     DRUG              INDICATION             ACTION                                CONTRAINDICATION           ADVERSE EFFECT       NURSING CONSIDERATION
                                                                  INTERACTION
Generic Name:       > indicated for the   > inhibits fungal    >alprazolam,         > contraindicated in      >CNS: headache,       >Serious hepatoxicity may
fluconazole         treatment of          cytochrome           chlordiazepoxide,    patients hypersensitive   dizziness.            occur in patients with
                    Vaginal candidiasis   p450                 clonazepam,          to drug and breast-       >GI: N/V,             underlying medical
                    (vaginal yeast        (responsible for     clorazepate,         feeding patients.         abdominal pain,       conditions.
                    infections due to                          diazepam,            >use cautiously in        diarrhea,             >if patient develops mild
                                          fungal sterol
                    candida).                                  estazolam.           patients hypersensitive   dyspepsia, taste      rash, monitor him closely.
Brand Name:                               synthesis);
                    > Oropharyngeal                            Flurazepam,          to other antifungal       perversion.           Stop drug if lesions progress.
Diflucan            and esophageal        weakens fungal       midazolam,           azole compounds.          >Hematologic:         >risk of adverse reactions
                    candidiasis.          cells.               quazepam,                                      leukopenia,           may be greater in HIV-
                                                               triazolam: may                                 thrombocytopenia.     infected patients.
Drug                                                           increase and                                   >Skin: rash
Classification:                                                prolong levels of                              >Other: anaphylaxis
Pregnancy risk                                                 these drugs, CNS
category C                                                     depression, and
                                                               psychomotor
                                                               impairment. Avoid
                                                               using together.
                                                               >Cimetidine: may
                                                               decrease
                                                               fluconazole level.
                                                               Monitor patient
                                                               response to
                                                               fluconazole.
                                                               >Cyclosporine,
                                                               phenytoin,
                                                               theophylline: may
                                                               increase levels of
                                                               these drugs.
SUBMITTED BY: Giselle Chloe B. Ico