DRUG               MODE OF ACTION           INDICATION            ADVERSE EFFECTS       NURSING
RESPONSIBILITIES
Generic Name:            It relaxes vascular    Indicated to improve       Hypotension        It is very
nitric oxide             smooth muscle by       oxygenation and            Withdrawal          important that
(inhalation gas)         binding to the heme    reduce the need for                             your baby's
                                                                           Atelectasis
                         moiety of cytosolic                                                    doctor check
                                                extracorporeal             Hematuria
Brand Name:              guanylate cyclase,                                                     your baby
INOmax                   activating guanylate   membrane oxygenation       Hyperglycemia       closely while
                         cyclase and            in term and near-          Sepsis              receiving
Dosage/Route/Frequency   increasing             term (>34 weeks            Infection           nitric oxide.
20 ppm                   intracellular levels   gestation) neonates        Cellulitis          This will
                         of cyclic-guanosine    with hypoxic               Stridor             allow the
Classification:          3',5'-monophosphate,   respiratory failure                             doctor to see
 Pulmonary Vasodilator   which then leads to                                                    if the
                                                associated with
                         vasodilation.                                                          medicine is
                                                clinical or
                                                                                                working
                                                echocardiographic                               properly and
                                                evidence of                                     to decide if
                                                pulmonary                                       your baby
                                                hypertension in                                 should
                                                conjunction with                                continue to
                                                ventilatory support                             receive it.
                                                                                                Blood tests
                                                and other
                                                                                                may be needed
                                                appropriate agents.                             to check for
                                                                                                unwanted
                                                 CONTRAINDICATIONS
                                                                                                effects.
                                                Congenital heart                               Your baby's
                                                disease                                         doctor also
                                                                                                needs to
                                                characterized by
                                                                                                monitor your
                                                ductal dependent                                baby's
                                                systemic blood flow                             breathing,
(eg, interrupted          oxygen levels,
aortic arch,              and other
critical aortic           vital signs
                          while
stenosis,
                          receiving
hypoplastic left          nitric oxide.
heart syndrome) and      Stopping
severe left               nitric oxide
ventricular               suddenly may
dysfunction.              increase your
                          baby's risk to
                          have rebound
                          pulmonary
                          hypertension
                          syndrome.
                          Symptoms
                          include:
                          bluish lips or
                          skin, slow
                          heartbeat,
                          lightheadednes
                          s, dizziness,
                          or fainting,
                          or decreased
                          cardiac
                          output.
                         Nitric oxide
                          may cause a
                          rare, but
                          serious blood
                          problem called
                          methemoglobine
                          mia. Your
                          baby's doctor
    will measure
    how much
    methemoglobin
    is in your
    baby's blood
    while
    receiving
    nitric oxide.
   Do not take
    other
    medicines
    unless they
    have been
    discussed with
    your doctor.
    This includes
    prescription
    or
    nonprescriptio
    n (over-the-
    counter [OTC])
    medicines and
    herbal or
    vitamin
    supplements.