Mindanao State University – Iligan Institute of Technology Student: Egao, Vanessa Jones C.

Section: Block 260

PHARMACOLOGY

DRUG STUDY

Brand Name: Tygacil__________________________ Generic Name: Tigecycline____________________________ Drug Classification: Tetracycline; Glycylcycline

Dosage, Route & Frequency Drug-Drug & Drug- Contraindication Side Effects Adverse Reactions (By
Drug Action Indications
Recommended Prescribed Food Interactions s (By System) System)
Complicated Skin Tigecycline inhibits Drug: Increased Treatment of complicated Hypersensitivity to Nausea, vomiting, head CNS: Asthenia, dizziness,
and Intraabdominal protein production in concentrations skin and skin structure tigecycline; ache, dizziness, or headache,
Infections bacteria by binding to of warfarin required close infections and complicated pregnancy pain/swelling at the insomnia. CV: Hypertension,
(category D) and hypotension, peripheral
Adult: IV 100 mg the 30S ribosomal monitoring of INR. intraabdominal infections. injection site may occur.
during tooth edema,
initially, followed by subunit and blocking Efficacy of ORAL Organisms susceptible to development of phlebitis. GI: Abdominal pain,
50 mg q12h over entry of transfer RNA CONTRACEPTIVES may be tigecycline the fetus; viral constipation, diarrhea,
30–60 min molecules into the decreased when used in include Escherichia infections. dyspepsia, nausea,
ribosome of the combination with coli, Enterococcus vomiting. Hepatologic/Lymphat
Hepatic Impairment bacteria. This prevents tigecycline. faecalis (vancomycin- Severe hepatic ic: Abnormal healing, anemia,
Child-Pugh class formation of peptide susceptible isolates impairment (Child- infection, leukocytosis,
Pugh class C); thrombocythemia. Metabolic/N
C: Initial dose 100 chains in bacteria, thus only), Staphylococcus [S.
hypersensitivity to utritional: Alkaline phosphatase
mg, followed by 25 interfering with their aureus (methicillin- increased, ALT increased,
tetracycline,
mg q12h growth. susceptible and methicillin- amylase increased, AST
intestinal
resistant perforations, increased, bilirubinemia, BUN
Distribution: 71–89% isolates)], Streptococcus [S. increased, hyperglycemia,
intraabdominal
protein agalactiae, S. infections; children hypokalemia,
bound. Metabolism: N anginosus group (includes S. <18 y. hypoproteinemia, lactic
egligible. Elimination: F dehydrogenase
anginosus, S. intermedius,
increased. Musculoskeletal: Ba
ecal (major) and and S. constellatus), S. ck pain. Respiratory: Dyspnea,
renal. Half-Life: 27 h pyogenes], Citrobacter increased cough, pulmonary
(single dose) and 42 h freundii, Enterobacter physical findings. Skin: Pruritus,
(multiple doses). cloaca, Klebsiella (K. rash, sweating. Body as a
oxytoca, K. pneumoniae), Whole: Abscess, fever, local
reaction to injection, pain.
Bacteroides (B. fragilis, B.
thetaiotaomicron, B.
uniformis, B. vulgatus),
Clostridium perfringens,
and Peptostreptococcus
micros.
 Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)

Assessment & Drug Effects Intervention:

 Monitor for hypersensitivity reaction in those with reported tetracycline allergy.  Avoid direct exposure to sunlight during and for several days after therapy is terminated to
 Monitor for and report S&S of superinfection (see Appendix F) or reduce risk of photosensitivity reaction.
pseudomembranous enterocolitis (see Appendix F).  Report to physician loose stools or diarrhea either during or shortly after termination of therapy.
 Lab tests: C&S prior to initiation of therapy; periodic serum electrolytes, LFTs and  Provide tissue care as needed.
kidney function tests; PT and INT with concurrent anticoagulant therapy.  Keep a sterile dressing technique during wound care.
 Monitor diabetics for loss of glycemic control.
 Assess site of impaired tissue integrity and its condition  Tell patient to avoid rubbing and scratching. Provide gloves or clip the nails if necessary.
 Assess characteristics of wound, including color, size (length, width, depth),  Educate patient about proper nutrition, hydration, and methods to maintain tissue integrity.
drainage, and odor.  Teach skin and wound assessment and ways to monitor for signs and symptoms of infection,
 Know signs of itching and scratching. complications, and healing.

Diagnosis: Evaluation:

 Impaired Skin Integrity  After 8 hours of nursing interventions, patient demonstrated understanding of plan to heal tissue
and prevent injury.
Planning:

 After 8 hours of nursing interventions, patient demonstrates understanding of plan to

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