mesoridazine
A Drug Study Presented to
Lendell Kelly B. Ytac, RN
Faculty, INAHS BSN-Program
Davao Oriental State University
_____________________________________________
In Partial Fulfillment
of the requirements for
NCM 117
Care of Clients with Maladaptive Patterns of Behavior
(Acute and Chronic)
By
Clint S. Ancog
Student Nurse, BSN-3A
March 18, 2022
Name of Drug Dosage/ Mechanism of Indication Contraindicatio Side Effects/ Nursing
Frequency/ Action n Adverse Responsibilities
Time/ Route Effects
Generic Name: Psychotic Based upon animal Severe CNS SIDE ● Monitor I&O
mesoridazine Disorders studies, Used in the depression and EFFECTS: and bowel
Adult: mesoridazine, as treatment of coma; prolonged ● fainting elimination
Brand Name: PO 10–50 mg with other schizophrenia, QT interval ● low blood patterns and
Serentil b.i.d. or t.i.d., phenothiazines, acts organic brain (>450 msec), pressure check bladder
may increase as indirectly on disorders, including ● blurred for distension.
Drug needed up to 400 reticular formation, alcoholism and congenital vision Depressed
Classification: mg/d IM 25 mg, whereby neuronal psychoneurose prolongation; ● pigmentary patients often
phenothiazines may repeat in activity into reticular s. history of retinopathy fail to report
30–60 min if formation is reduced arrhythmias. ● tardive urinary
Chemical make- necessary without affecting its Lactation dyskinesia discomfort or
up and effect: intrinsic ability to constipation.
Mesoridazine is a Dementia activate the cerebral ADVERSE ● Monitor BP
phenothiazine Behavior cortex. In addition, EFFECTS: with patient
substituted at Geriatric: the phenothiazines supine and
position 2 (para to PO 10 mg 1–2 exhibit at least part CNS: standing.
the S atom) by a times/d, may of their activities Dizziness, ● Report to
methylsulfinyl gradually through depression sedation, physician if
group, and on the increase q4–7d of hypothalamic fainting, patient
nitrogen by a 2-(1- (max: 250 mg/d) centers. extrapyramidal complains of
methylpiperidin-2- Neurochemically, effects, blurred vision.
yl) ethyl group. It Management of the phenothiazines dystonic Periodic
has a role as a Hyperactivity are thought to exert reactions, ophthalmic
dopaminergic Adult: their effects by a akathisia, examinations are
antagonist and a PO 25 mg t.i.d. central adrenergic tardive advisable with
first generation up to 75–300 blocking action. dyskinesia, long-term
antipsychotic. It is mg/d neuroleptic therapy.
a member of malignant
phenothiazines, a Alcohol Pharmacokinetics: syndrome.
sulfoxide and a Dependence Absorption: Readily Special Senses:
tertiary amino Adult:
compound. PO 25 mg b.i.d. absorbed from GI Blurred vision,
Mesoridazine is up to 50–200 tract. Peak: 2 h PO; xerostomia,
used to treat the mg/d 30 min IM. nasal
symptoms of Duration: 4–6 h PO; congestion.
schizophrenia and Anxiety & 6–8 h IM. Urogenital:
reduce Tension Metabolism: Urinary
restlessness, Adult: Metabolized in liver. retention or
anxiety, and PO 10 mg b.i.d. Elimination: incontinence,
tension. It can also up to 150 mg/d Excreted in urine ejaculation
reduce and bile. Half-Life: dysfunction,
hyperactivity and 24–48 impotence,
uncooperativeness. Pharmacodynamics priapism.
: GI:
Mesoridazine, the Constipation.
besylate salt of a Body as a
metabolite of Whole:
thioridazine, is a Decreased
phenothiazine sweating.
tranquilizer. Skin:
Pharmacological Rash,
studies in laboratory exfoliative
animals have dermatitis
established that photosensitivit
mesoridazine has a y.
spectrum of CV:
pharmacodynamic Tachycardia,
actions typical of a orthostatic
major tranquilizer. hypotension,
In common with arrhythmias
other tranquilizers it (prolong QTc
inhibits spontaneous interval) heart
motor activity in block.
mice, prolongs
thiopental and
hexobarbital
sleeping time in
mice and produces
spindles and block
of arousal reaction in
the EEG of rabbits.
It is effective in
blocking spinal
reflexes in the cut
and antagonizes d-
amphetamine
excitation and
toxicity in grouped
mice. It shows a
moderate adrenergic
blocking activity in
vitro and in vivo and
antagonizes 5-
hydroxytryptamine
in vivo.
Intravenously
administered, it
lowers the blood
pressure of
anesthetized dogs. It
has a weak
antiacetylcholine
effect in vitro
References
Schull, P. (2013). McGraw-Hill Nurse’s Drug Handbook Seventh Edition. McGraw-Hill Companies, Inc.
Skidmore-Roth, L. (2021). Mosby’s 2021 Nursing Drug Reference, 3251 Riverport Lane St. Louis, Missouri 63043
Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. Drugbank: a comprehensive resource for
in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34 (Database issue):D668-72. 16381955.
