HEMAT QUIZ
1)A 40 year old cigarette smoker is found on routine physical examination to
have a 1 cm white patch on his oral mucosa that does not rub off. There are no
other lesion the mouth. The patient has no risk factors for HIV infection. The
lesion is non tender. The next step in management is
A) Culture for Candida albicans
B) Follow lesion with annual physical examination
C) Refer to oral surgeon for biopsy of lesion
D) Reassure patient that this is a normal variant
2) A 60 year old man Presented with fatigue ,weight loss and heaviness in left
hypocondrium for six months hemogram showed Hb10 g/dL ,TLC 5 lakhs/mm^3,
platelet count 4 lakhs/mm^3,DLC shows neutrophil 55%, lymphocyte
4%,monocyte 2%, basophil 6%, metamyelocytes10% myelocytes18%
promyelocytes 2%and blasts 3%. The most likely cytogenic abnormality this case
A) t (1,21)
B) t(9,22)
C) t(15,17)
D) Trisomy 21
3) 60 year old person presents with history of angina and shortness of breath for
the past week. Blood withdrawn shows thick Brownish red color. Diagnosis?
A) Sickle cell anemia
B) Hemolytic anemia
C) Meth-hemoglobinaemia
D) G-6-P- deficiency
3) A 35 year old female who is recovering from mycoplasma pneumonia develops
increasing weakness Her Hb is 9g/dL and Her MCV is 110 .The best test to
determine whether the patient has a hemolytic anemia is
A) Serum bilirubin
B) Mycoplasma antigen
C) Reticulocyte count and blood smear
D) Serum LDH
4) Features of Von Willebrand disease are
A) Increased BT and PTT
B) Increased PT and PTT
C) Increased PT
D) Increased CT
4) A 29 year old woman develops Deep vein thrombosis (DVT) in the third
trimester . Which of the following statements regarding heparin therapy is
correct ?
A) affects heparin synthesis of factors
B) is monitored by prothrombin time
C) is contraindicated in pregnancy
D) may be neutralized by protamine
5) Patient was treated for Mantle cell lymphoma with radiation . After 6 months
he develops an electric shock like pain along the spine on flexing his neck . What
is the diagnosis?
A) Cervical arthritis
B) Lhermitte sign
C) Uthoff sign
D) Spinal cord compression
6) A previously healthy 49 year old man presents with fever and night sweats. He
has splenomegaly . His peripheral white blood cell count is 22,000/microlitre and
a peripheral smear shows immature leukocytes with basophilia . Leukocyte
alkaline phosphatase is low and vitamin B12 level is elevated .For the above
patient with cancer select the most likely risk factor for the malignancy
A) Helicobacter pylori infection
B) Hepatitis C infection
C) Mutation to BRCA1
D) Translocation between chromosome 9 and 22 [t(9,22)]
7) A patient presents with a platelet count of 700 x 10^9/L with abnormalities in
size, shape and granulity of platelets. WBC count of 12 x 10^3 L, hemoglobin of
11g/dL and absence of Philadelphia chromosome . The most likely diagnosis
would be
A) Polycythemia vera
B) Essential thrombocytopenia
C) Chronic myeloid leukemia
D) Leukemoid reaction
8) Peripheral blood smear shows smudge cells which is the next investigation
A) Cytogenetics
B) Flow cytometry
C) Bone marrow studies
D) FISH
9) Which of the following is a disorder of platelet adhesion
A) Glanzmann's thrombasthenia
B) Bernard Soulier syndrome
C) Wiskott Aldrich syndrome
D) Hermansky Pudlak Syndrome
10) Individuals with a lack of which of the following blood group antigens have
immunity against Plasmodium vivax
A) Kell
B) Lewis
C) Duffy
D) Kidd
11) Cryoprecipitate is useful for the management of patients with all of the
management of patients with all of the following conditions except
A) Hemophilia A
B) Von Willebrand disease
C) Hypofibrinogenemia
D) Christmas disease
12) You are monitoring the falling platelet count of a 31 year old man with
dengue fever. You would recommend prophylactic platelet transfusion when the
count drops below what level?
A) 5000 platelets/ microlitre
B) 10000 platelets/ microlitre
C) 15000 platelets/ microlitre
D) 50000 platelets/ microlitre
13) Which of the following blood components does not carry the
risk of transmitting cytomegalovirus infection?
A) Packed red blood cells
B) Whole blood
C) Fresh frozen plasma
D) Random donor platelets
14) According to WHO 2022 classification which of the following is not a chronic
myeloproliferative neoplasm?
A) CML
B) Chronic esinophilic leukemia
C) Essential thrombocytopenia
D) CLL
15) Most common myeloproliferative neoplasm?
A) CML
B) CLL
C) Polycythemia vera
D) Primary myelofibrosis
16) May hegglin anomaly occurs due to defect in ________ gene in chromosome
22q12-13 region
17) Most common malignancy seen in Fanconi's anemia is____________
18) Bleeding from umbilical stump seen in which factor deficiency and what is
the other name of the factor?
19) Variant of E. Coli causes Hemolytic anemia?
20) Name two two hematological disease conditions where hyposegmented
neutrophils are found?
21) Bone marrow aspirate in case of children is taken at which site?
A) Posterior lilac crest
B) Sternum
C) Anterior iliac crest
D) Shin of tibia
22) The major criteria established by the National Polycythemia Vera study group
for diagnosis includes all of the following except
A) Increased red blood cell mass
B) Splenomegaly
C) Leukocytsis
D) Arterial O2 saturation ( greater than 92%)
23) Which cluster designations are positive in typical HCL?
A) CD25 CD11c, CD19 ,CD20
B) CD25 CD11c, CD19, CD10
C) CD25 CD11c, CD10, CD5
D) CD25 CD22 CD19, CD20
24) Risotectin test in Von Willebrand disease shows
A) Increased Agglutination
B) Decreased Agglutination
C) Normal Agglutination
D) No Agglutination
25) Popcorn cells are seen in which subtype of Hodgkin Lymphoma
A) Nodular Sclerosis
B) Nodular lymphocyte predominant
C) Lymphocyte rich
D) Mixed cellularity
26)__________ is tyrosine kinase inhibitor and used in the treatment of CML
A) Omalizumab
B) Imatimib
C) Rit
