Page 1 of 31

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Unur-L Mine
Date /O| /20 2

Ca Ckbobyducttesutahaism

enugu e iuing_C aboydnol

bexalbalik i
ADaO WAi oochmiau and
rew
mutabolic process
CUmulateA (cooiuns p
p0cess wuch aModcousm cotaboism
CM VuaS wleNaVe rsim LanknhsdrsA
ak plocs=
Colabolis
ell
uskeu lag molicwles Small ol +Eing
amalbtlim

h mabSacchaid lucoua Coual

Canbohydnda tabalusn_Sh
Ph

dad Moron Cosbnud

utauab
2oNornqorl9 osmaT
Glytolycis
arm

He- Glyco Gluoe SUGad-0-

Breakdown/aisoluh n

is h mcduuve d
a

ur0nk_ Clyoty GluLatebakdr

EISdufinmd4
zonAxN 2nt-Cmreaiin LuCA iroPyavale
OMa cake wilh h pAnduehm gEATP

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Min
Pathw ay wa disovened byH Hwo Bio - chimast
tmbden P
Meyrnef30, i alo Callud
&M. pathway).
Ca GHLYCOLYSIS
ATP
Phsphofudotvas
3

epprut)|
HO-(-H
rew
H-C-9H
H (-CH
HO
H
OH-C-H
H--01
H-C
C
H-
Gluco so
ell
frocost 1,6-bbposphdti
ATP uxoLinal
Glucokivas Aldolas
APP
HO
H =0
H-C-04 h-0
Phbsphobioce
Ph

Iomuasa --6H
H--H O

hOH
Glyceralduhudt
Dihyoonyaulon
3-phosphat
Ch-0-
arm

phosphalr
uraldulayda
Gloou-6-phosphati
NAD -Phosptati
Phespholayos deluydad gunale
+H

--
NADH
ionALras
CHOH

C-04
H-C-OH
HO-H
a

H-C-6H
H 4,3- Bicpho phoalyan

trucost-6 -phoiphal

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Mind
ADPR Phosph@qycualh
(ina
ATP
C00 C00

H-C-GH
Ca
G4-0-
3-Phos phoqyaal Aovati (uto)
rew
Phosphrg lyuai NADH + Ht Locale
mutas dahydrogovna
NADt
Co0

H--0- -C-0H
Ch-0H H
ell
2-Phoshoqlyuali
L-Loctali
ndas

-0
Ph

Phospio eelpyat (eP

ADP
Hyuvati
gt
arm

Cingse
ATP
CO0

-DH
Uh
Pysuvali (onol)
a

Spbudrouuovp

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Mn
Date://20
s10 Page:

-0
The palwd owts hcephas
Ca SMIngu phai
Spliuthig phas
u) quLnaK m bhaso
rew
O 4g inestmo phal
phosphoryAatedto
Clu oS 6-phochhs by hakOwxo tina
Hu rxn ie.ersiblancopendsdom
ATPthi enzyma huxdeina
ell
3Av
ehzin qlbcounas
schn ctayCs
phosphoahn d alute muy
O
Gluco6-phosp hali
He
Ph

cto S phoiphe
-6
hosphohxpsOmeAake
24MAodiia
arm

ch6-phasphot i pijdezykatal
6-bis phpiphauD4 2um n
phetphOrmtae
n
ina
phale
a

Th Six oabm
SasbncOamd copand,Gluceralda
pAphelk Oud dihydanxy arolom Ipheiha
enzLmL aldepkaialdalá2

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Date:
Page

Th engumLpho spho bosisomoiaC Cataly21 2erekiLl

Ca
wleloM reKsim Gycmaldsudi plhosphai
Dihydgay0cuonephbsphau
pwd

E9 quhnh m phak
rew
AO) 2

Gluaalddh-phos phatr Cnveredono 1kBisphogn-

alucuai ih ho hlh of enzym
Glumeldhujd 3-phosphat duhuydangn
9AN 093-
)Thenzyma phosphoglycuaat na ac m3bis-
phosphoglycera Sulhing Sunthuis OF ATP nd
ell
3Phophoqlycurate
00 3
D3-Ph0sphogluuu u cmverted into Phosphoqlucrau
hulb en2m Phospho glyuau muja co

nzymu
Ph

enbla 4unnati phosp hopnok pyauraa

N)Th& n zy m pyru vaa CRnol catryzed th

igh eneypnosphatt pen
o
arm

phosphoen al pya/el Pep)_ ADP leadihg

oma ATPnb2

thi, EnLRGETIS 2 NÍSo- H2A)

DONIU20loxO 190p
STEP ATP CoM SUMED ATP qaind
OL L
(ainid
a

03
Aota
etaoput
keg P 8 ATP

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o TCA (Thitanooxyuc acd) uycl
cebs ydu
Pysuvali
- coD

duyduogeMakA
Ca CoA--
NADH+ H L
COL
SCoA AehyR CoA

CofnSH
NADH+ H h-0
rew
Ctba
-Co0
Synhauu Ho-C(60 ,hO
NAD Malati C-C00 Ch-Coo
dulhydsogana Oxolbqcelati
Acovutos
ciba -Coo
Ho-1- Co0 Co6
L-Malal
Cis-Arcovitalt
HDfumaras
ell
H--CoD fraitas

fumaualr ChCo0
Svccinat -Coo
fApH duhydroqunas
Ho--o
fAD Toánat
Ph

Ch-0D Todnal NAD

dihuydngensi

Sucainai NADH+H
Suctina
arm

GTP
CoACH hotinaL CH-CoD
,Oh-lo O=t-coD
10P Oxals suceimi
CSCoA Ioúhal
ydvogus
-kotoglularali
Sucn
CoA
dblhucdabgenade Ch-Coo
Cah C0
a

NADH tH AJAp
(02 CoA SH
O=C-Cco
-keloglutarai

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Mne
Date: 120
Page

mos wh
Ca
SUupplu
waluee
tic acidiCydi escohllu
DApNitho
he Oudoh o acoy co-A
bodip

o CaubondioidAidlolain iheCbncactd Oudakue pathKau

Cyc Naoihelibhcomma
rew
Conowdhoa palhwa
ma emde
Aupplyna eng buHorauo povidb

Homo ho enzymep of TCA(iaabo

bcatnd on Mitochndiia mamx
a tu iMCordniohm
ell
DHomahm efGbag
_Acyk -A aud Oxalo
autal Catayzad by enzyna CUlo Suntihaso

Chatr omuricu ln ispCiaT by tha nzn

AcoiutaS
Ph

-tRkoglutarae as ezYmi isð

enmahm O
cuuakr dahydangunatt
1 Cotalpid CaeslMDH 10-iharto
arm

OxaloxuccinatrT AAud
of (Oa
formaha NADHu uauah
OcCwrs aFr Mi AtaqRA ailurooln

VE) onversiom
0 -olbglupratp pAKCY
TA thiagh OxUdahe dimaboa lahen
a

Cotate -etaglutarala_dihydAngemas
SUcCinau
(Nil) halim oE KcInarbienzine
MiotiaUL

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-Mine
Date: /120

Page:

VI

enzym
Ca
Conerslom
OF A CUctnai toiumar
ixcinalioi dhudnogsnas i
urrar
ixemahmof Molai h Onzumi
rew
AiHh tu addihm twam
ALN

Conerclmbi OfOimalatr ooiOxaloactai by

221 2N9
ell
STer
ATPbunCoSUMep ATeGAINED oATP
3o 0- NoP Gaiwd
Ph

12niiNo

oiOxidahm0F GlutocOOT UlbaiI- min

arm

adih-i Glucolyauon2 ArP Aato

Wointubnle Oxidaho of a

iakoxylic -AcidTCA T_LLg ATP

(Gi aud ycla)
uniab ihtDLdttS? 9TA
a

ONADOAhMi bifuyt-o

DoNIDU2
1ONai

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9M Mine
Date:
ele 120
rage

Signfianu. Ca rabamnalo
Aspantai
Oxalosucuinat dear
Matate
rew
O-Celogwtaral TranuhaS
Nm-essoia SuCcinyl (oA
Amino aud Glutma
Porinos

Pupinudins
h cubM aud uda ic th most impaataut nubbic
ell
0alhuyfo enLngu Aupplye
alodu ATP Aunthigizud in
Kb auclu
HOXOS& MAhonluashhat hunE Pana
ahurau
Ph

i alD knwn pOmosiphosphalThú

On allkanahw pathuay glutalyA and
TCA oxdohon Of
pouhuay ytosal u pathwiay
arm

duudiud phase

Oxidahve pht
2 Nm-Xidahiue phae
a

HO-3 H

9.019

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HO-C-H Mine
nM Date: 120

H-C-b P8ge

Glutos-6-phosphai
H O
Ca H
OYOP
PAlsy
NADP dthydrngmaie
atluastphosphit
rew
NADPHTFH

H-(-0H
6-phosph0aluco adowL
HOC-H
H-oH
ell
T
tvtoldétenAydialas

220
H C- 6-phophoqtuconatr
Ph

NA
120
arm

CLhOP
D

NADp
hh
phosphoqluCOnau dihydmoairas
NADPH+ H
9A0Na 9wrlohix
toz

=0 Riuloce-Sphosphal
H-c-0
a

Ribuloskphospi,K

Ribulbsl etosgM

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SniM Mine
Date: /20
Page

1opotibu 2-20 H-e

Ca
OH JA130lova
rew
-Uwwho Xuiulosa-p i dhvcouioaiaia Ribouk-p
Jorh2onNn-720ord D
rans@rolas
ell
H
1UNNJTY

o blhwn)Glucoraldthy di-2-p
Ph

rans saldolaki

og C-0

HO
arm

H
-H
-H
hshlnsoni obal
fruthrose-H-phospha AGuCH0P
tucoc-6- phetphilt
Trauskutolaua
a

Glyaraldahuyda--p
Kovesal o
gLuralysis
fwctose 6phoaphili

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Mtne
Date:
/ 120
ee Page:

OxLdahve pha aluos-6-p dihudrogznas(G6P0) an

Ca NADP dopndet onzym o conveut alurO
R-phDsphal o 6-phesphogu Colacton
T 6-phekphoqluolactout Mydrolyaad-fo 6-phosphogluons
Th Myt XD Involes thnhulSyntuik NADDH4
-phaphagluxonali dihydngana procuc
Catalytady
rew
3eo Jn6-phaphogluonai wlidh tun AMding0A ciCOAOAY=
ahon o qie Phulosu 5-phosphai

Nm- Oxidahwe pha

MA phas is CmCorud in onersiom 3Y.SA (arbon
mano Saccharidu Libuloti S-phosphai
ell
Xululbs phosplali in-
fpinuru nzym at on it
And hn tetoiomores nzymatton zibalust S-pheaphali
0u onveated ibose s-photphati
In xE Skep
hae i raufa of carban rom
Xuylvlbta -phosphati
ibosa S-phosphat to fon
ad Canbon)
Secdohuhhbulot -phosphoti E aud Glcraldoluydi 3-p
Ph

wih t hulh enzum rangholal

eN2uML panaldalosi OAing tu 3Canb@n nmoety
(oMhom (ompoind to 3 Canba
Compound Glyceraddiydi -phoiphalr o QIue fwdos 6-p
arm

four Conh0m fhose -pheipha

troneolaJk zym AcE 0n myhrosge--
Gluceyeldeyds-3-p AMA
PeveAibl glurodyai
mala
a

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pM Mine
Dato 120

Page

StonihtcauntQ HMP A ULqu qenuraHuo

hdapoutout
Ca pbdu /3 mee dsdfn he
biostmslSmCHeactiou othr funchons
DPentoses nuhiahNi bfhsin
NAD PH 99
rew
LN eTmp.F Pontosuk N uHMP AhurtyniyossOK (meaed
nbi p.0ntosuy H mosE impotnMT being
mbost-phosphol. Thi neutoS
dauvaiie 0 OA
USLfu tu2yuthuisDilof nuddicauds (RNA ad
2 DNA) Hand (MaMy nudeotidusAUdhaNIAP, NED'HAD
ell
BA
Alop
2 1u hiQuned fon
NADPH1
Hducthve
ulonnr
daluih or
biosunthesisothti
LALAnndúda urand isa Aeraid 20uRhw
s ni2hagoiaytasiso ikaxtainengulfmuxt iofoarigniipaaticoa auo
Ph

Controlw2th produdhon of HDgby anyiexi

A DoH
99 Owhioxicdaut(hearadicasawenginq)anequid
y ADmingdutoxificokionf
aD Ayxtem Cin liver
f4igait by umcuytochomu lus
hydioxytahon involving NADOH
arm

5 ln esCautial o
uaintan uaionit
RAC mlwb rand
necsary 0 oep frros Îm (fe
hum0gkobin in HdvcedAtab SD at
accumulahion Mutheuogdobin te3+)
6Hh coenkahon of NADDH in len bf eyes
a

MeuSsan prtserve Hrandpotny of thl lehu

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M Date: 120
ge

Glutoco6-phespatu otuydtocunas dedency Sex-Linked

G6PD Ca dafeceby Qhiahuitd
bA

Hrait Athough th dutecientinocorlanalmon

alfe ched indiuuduals. la l
HG4 A
NADPH
h Dly MAO Oprouaiginpaig
rew
HMP Ahur
n ihan hYDLyKA.DI[KASLd RB achuia o G6PD
Suntatais 10NADPH ln Thu Hiult in h
accu.mulahn f nuHhthaglo bin andpernxicu
1erutbrocyt l0adingubhimoly
Mos
nai iTdincol yaifEAjahnalin G6PD b dufiuena
Hho autei enu do nst
ell
usually- exhibiE uinilol umppma So ofhim
hou:AVr£A. dRlOp himoluti
Qdnmivisterd ni 0aicdau daugso ixpocidt Si
infechion Tu Auth Akpaimaquint itawtimalanld
das
autaniidLvehpunlkl)y SulfanauihDXAZAl (Outibigiht) oingeln
Ph

D fan beansGavicm_pdduca hinalyhiceeiauin in

thn the nts SeeAnlnethimt Sultin t 0urahin
OFaLfRiradical in mitoph.ngeA Whithn Canientr RRC
AndaiuR hanokyA LOuL HidiHACIdiNADOH aN
arm

neduud GSHh
Lot22 9
DNDTG iAN 9g
UN 02203LN
0ID
dbt bhawh

iiOluinuin
a

HaaGN_a adnom d a
NO22039

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Mine
Date: 20
Fage

wNi GLrco GENNESIS

Genusu
Ca
luco2Glbcogan
Sunthuiy fOAmahen

GluLos
rew
ADP-
HeXonanGlotoki nas

Phospho 9TDCmutast
lpM2 Ar
ell
GlutON -=ph0sphai

luNi ubauDPNaPhosphbnya ina

upP GlucosuAidk diphospha)
Ph

HO) qUOD YONAN

Glucequnprimar
13/D0-4)
y (ogn yhau
arm

13UDP

Glucosu(«H,k-tranaferass)
a

2awlo
Shre

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Page

lmgahm by Glyogtn Aynth

Couming ( 1,H-bmd

Ca Bnanthi
N
hasfa
GLYCOGCN

UDP
rew
ym xokino
Sundhuu of nGlutoc Tuenz GloleiL to
GlucokinaA (mvnE
GlULoe-6pPhoi phoglucomutaa Cmveut
phb 4-fP
G-1-p wlch hon Convet o UDP GIung

o enwhalnniaGlycogpniU3A cma
2eauHmoAt of_paima
alycogh mUs
ell
AL-Oxishng
ef Sumthui
uE a piman ohuahar oi 4lucoun ApLciHC |

npaskein h nhiin
amuly
ofAycagan
ülycounau
pima A
Con accept guoi
UDP
adtacho d aF ydnoxy OUp (OH) h
Ph

glycoqundn

GlucoQun Unhu by Pnzum 4luo0AM SUhakr TH U

Iponuh
arm

pm
inkag byhaeAMg
o
t h Qlutot
UDD GluLes man-2eduin udAf gluugn

(9Houn@hm L bAainchlAEngly.cmgun M
PMam
Qlyth ty 6-panitenasL_panien a Anall
fmgos aluco ar mM
a

o QMsthNouoA
LKlinkg
wwL
Chomda. T glycegan
Sunkhodby
ukun eloganof

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Mune
Date: 1120
Page
= U,s
alyaqnApthaA 2lyrosik ansfesase
Ca GLYCo GENOLYSIS

aycoqrne--alycogAn
2ySik- Bxakdaun u
rew

Gy ogn
ell
fondon orl onLALA
atycoguM ph0phooyaua
Ph

K
arm

NS NI LiniuhuDexbin
Obianchuig
Onzm (Yaauusfe ase acluu
a

Duband Enzym
etotos Y (,6-Gucotdaal ehe acw

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P Mne
Date: 20
Page:

Ca
Glyrelysiii
Phosphaluyomutz

--6-P
Gvtou6-phophaha
Glutosa
rew
OAham of lycaq.an pheaphorylaxs t -L4 bomd iA
bn4niglyocun phcsphrylau Ho
olucota-phis phali hiApo(0u ald
phosphouctin h gluLun_S5fomid u
ell
lmit dixain wuch Conb et
bs dignaitd
uHu enyniglaguagin pho.miaczylas
(DAtim o0-banthing-p2jnl Glytosiahawfera

3.4-GlocaL2eida atachad at h manduo

Ph

Chaun
f amylo -LA-Glycdsidass
bono Telalu qlucosd
femaies
p
arm

enzym dipnol
G-6-phosphoatnil-that eekeas ceaf C6-p
oduluroieA ehzym pALLu in Liven udh
Bntehin n
ahu mUscl bnaLy
a

nepss PNJADNOKiud

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Mine
Date: 20

ge:

RequlahanDEQlycalysts 2 Glytoquis
Ca ATP tivetTalooR
9VNEA
rew , EAmP

PsGycogo phosphovytat
inhubhio
stnulahm CGilycogen CuOSA-1phoshai

923
aycogun sunthy -6-P
ell
Alosleic Pequlahen
2Hommal
2Requlahm by Lat

mmal eqvlahm
Ph

CciJ0ou AMIO )

Glucagon Nou epinpmihL

arm

Attny
GtaGlutogtn Cyua pau/d
po plas
Inacive -D

ATP cHmP
a

GtlGs inachi
Paiva tivnaus

PRosphwayt
G Sb

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: efod
Mine
Date: /20
ep Page:

Glucagem NE
Ca )
AC
inachie
rew
ATP CAMP

Glycoqun GluLos Anas

Lp
Phopoyase Pnosphonyloa
nachive ache
ell
phssplhmaal
resup al2oii

cainlunn
2eegulalbbn hi lalkium (Ca1)
Ph

SoCoplasicAuhaulum)
irndgtid9 rettttt
Achyat Laraa lin@u
arm

PhosphDrylahon

30 luwgm G-6-P poull

laAN)
a

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Ca
rew
ell

EFERE
Ph
arm
a

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Mine
oniM Date /20
otat

qlococ Ca lw ShhisÁS om nm-calooydnaA

a GlUCo S&
ATP
HOXOinaco
phoyphatat
rew
A G-6-p

af-6-PPa
fI6-0s
pho'phat 6-biphephl
ell
LGly curaldud )C-3-P Dihydooxyaaloiu
tApOsphali
1,3-8isphospha
gIyurau
Ph

SPhoihogly rak

PhoAphoqy corad

PhO AUA
arm

Phokphsenelpyuvau PEP)UD
l s2Oxaloaua ina AAS
LDH )) Pepirat Lactar
7ftaoeuek
deluydioguek

OXaloauai uL)
N
a

Mauu atatc eaqlutuatr

TALLON
AL uiNhSucunat

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Date
Page

Rea chonk

9
Ca
LonvtAion
ake
of pysAMCit-o
plat Ah uD Ae
Conlooxylase
p
CMNeNt
Pysuvat ehetphoeno
2equlate alu(oCLnLDOnoA
thi enzym
CoAfan achu
rew
Qud autyl
phoxharheo
PEP aAhox Eiae_cowent Dxaloautch
pywva LeLp)

2 vesim t6-Bisphosphal oif-6-p2

PeP
L-Bikplaaiphal u6-Bisphephkjo
andutad Hhsh phzymL-1i
ell
pheiphatzu convtat ais
gnig212

owcKi
Catalucid l
Mzy m -6 pkophata
Ph

Sanaiau
Gluoe anny4
arm

App wAgy Aclitan 0USdpA

acumu lau blod
X lacai glucerol ek
So Guco moquA cleon uú muabalL
bled
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Date 20
Page:

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Mine
ptod Date /20

Page:

Cdietnyonydaktd alucogenolysis olycouogensi's ett) oncl

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NHlzahiomd blood alucoseln A

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nM Mine
Date: /20
Page:

o Thuoxi AAahamo ofithuroid aland 9 elevak

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USualliyktheingymptom afdiabekiappAaIAOMen 3o-40

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(Siological oxidahon
Min
Date: I120
Page:

elechvon Tasp.0eiiChcin 1ET)

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Mine-
Date: 120
Page:

CoewiynA tish poicon roktm

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swtheushiLaATAnt2

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