Estrogen is a hormone that’s used in hormone replacement therapy (HRT) to treat symptoms of menopause, like hot flashes, night sweats, vaginal dryness, and mood changes. It can also be used in fertility treatments, to prevent postmenopausal osteoporosis, for feminization in transgender women, and for managing prostate and breast cancers. Additionally, estrogen is a common ingredient in many birth control pills. There are many forms of estrogen therapy (from pills to patches) with a range of costs.
| Drug name | Our lowest price ( with free signup ) Our lowest price ( with signup ) | Coupons |
|---|---|---|
| Estradiol | loading... | See all discounts |
| Prempro | loading... | See all discounts |
| Premarin | loading... | See all discounts |
| Combipatch | loading... | See all discounts |
| Vagifem | loading... | See all discounts |
| Imvexxy | loading... | See all discounts |
| Estradiol Valerate | loading... | See all discounts |
| Dotti | loading... | See all discounts |
| Lyllana | loading... | See all discounts |
| Yuvafem | loading... | See all discounts |
Health insurance (including Medicare and Medicaid) often covers generic versions of estrogen, like estradiol. If insurance doesn’t cover estrogen therapy, such as brand-name medication, or if your copay is still too high with insurance, you can still use a free SingleCare savings card to save on your prescription.
Using a SingleCare coupon is easy.
Search for your prescription on our website or app, or use the links to popular estrogen coupons above.
Enter the correct form, dosage, and quantity for your prescription to ensure that you receive the most accurate price at the pharmacy.
Show your pharmacist your SingleCare card when filling your prescription.
You can save even more money on your estrogen prescription by signing up for our free loyalty program. Members get our lowest prices and earn extra savings each time they fill a prescription.
| Drug name | Coupons |
|---|---|
| Estradiol | See all discounts |
| Premarin | See all discounts |
| Estrace | See all discounts |
| Menest | See all discounts |
The cost of HRT varies by form, according to The Menopause Center.
HRT pills cost $130 to $240 per month, or $1,560 to $2,400 per year. People with insurance typically have a copay of about $30 per month for HRT pills.
HRT cream, patches, and gels cost $120 to $1,020 without insurance coverage, or $1,440 to $12,240 per year. People with insurance typically have a copay of $60 to $360 per month for topical HRT meds.
HRT injections cost $480 to $4,800 per year without insurance and $288 to $1,440 per year with insurance.
Generic oral estrogen pills are typically the cheapest option for estrogen therapy. For example, generic estradiol costs less than $20 for a 30-day supply of 1 mg tablets on average without insurance.
The cost of estrogen patches also varies widely. For example, brand-name Dotti costs an average of $215 for one box of eight patches, whereas Combipatch costs an average of $300+ for one box of eight patches without insurance.
Estrogen cream and gels are slightly more expensive. Brand-name Divigel costs a little more than $200 for one box of 30 gel packets without insurance, and generic estradiol gel costs just slightly less.
Vaginal suppositories like Vagifem and Yuvafem are similar in cost to vaginal cream and gel.
Injectable estrogen is less common and also more expensive than pills and patches. On average, brand-name Delestrogen costs $236 for 5 mL of 20 mg/mL, and the generic version ranges from $109 to $216 without insurance, depending on the pharmacy.
Estrogen pellets are not approved by the FDA, so they are not covered by insurance. It costs $1,050 to $1,400 for women and requires two to four procedures per year, according to The Menopause Center.
Although out-of-pocket cost is an important factor, side effects and convenience are other considerations when deciding what formulation to use. Seek professional medical advice from a healthcare provider to choose the best medication for you.
Yes. Insurance, Medicare, and Medicaid typically cover generic estrogen for medically necessary hormone treatments and preventive care.
Estrogens: Uses, common brands, and safety info, SingleCare
How much is estradiol (Estrace) without insurance? SingleCare
Does Medicare cover HRT? SingleCare
How much does hormone replacement therapy cost? The Menopause Center
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