이 기사는 세포 접착 분자에 관한 것이다. 공식적으로 CHL1로[5] 촉진자 슈퍼 패밀리 를 참조한다. 신경 세포 접착 분자 L1 유사 단백질 은 L1 (CHL1)의 밀접한 호몰로크 로 알려져 있으며, 인간에서 CHL1 유전자 에 의해 인코딩되는 단백질 이다.[6]
CHL1 은 L1 과 밀접한 관련이 있는 세포 접착 분자 다.멜라노사이트 세포에서 CHL1 유전자 발현이 MITF 에 의해 조절될 수 있으며,[7] 유사분열 중간 단계 동안 헬리코아제 단백질 역할을 할 수 있다.
그러나 단백질은 동적인 국소화를 가지고 있어 세포 내에서 여러 가지 역할을 할 뿐만 아니라 다양한 위치까지 가지고 있다는 것을 의미한다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000134121 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000030077 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Pandey, G.; Kanwar, P.; Pandey, A. (2014). Global Comparative Analysis of CBL-CIPK Gene Families in Plants ISBN 978-3-319-09078-8 ^ Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, Eisen JA, Lerman MI (September 1998). "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules". Hum. Genet . 103 (3): 355–64. doi :10.1007/s004390050829 . PMID 9799093 . S2CID 3177127 . ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x PMID 19067971 . S2CID 24698373 . 추가 읽기 Chen QY, Chen Q, Feng GY, et al. (2005). "Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population". Schizophr. Res . 73 (2–3): 269–74. doi :10.1016/j.schres.2004.06.001 . PMID 15653271 . S2CID 40310550 . Manderson EN, Birch AH, Shen Z, et al. (2009). "Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer". Int. J. Gynecol. Cancer . 19 (4): 513–25. doi :10.1111/IGC.0b013e3181a3cd38 . PMID 19509545 . S2CID 27315616 . Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score" . Mol. Med . 16 (7–8): 247–53. doi :10.2119/molmed.2009.00159 . PMC 2896464 PMID 20379614 . Tam GW, van de Lagemaat LN, Redon R, et al. (2010). "Confirmed rare copy number variants implicate novel genes in schizophrenia" . Biochem. Soc. Trans . 38 (2): 445–51. doi :10.1042/BST0380445 PMID 20298200 . S2CID 31716113 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gast D, Riedle S, Riedle S, et al. (2005). "L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas". Int. J. Cancer . 115 (4): 658–65. doi :10.1002/ijc.20869 . PMID 15704102 . S2CID 44309818 . Lim SD, Stallcup W, Lefkove B, et al. (2007). "Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells?" . Mol. Med . 13 (3–4): 160–5. doi :10.2119/2006-00070.Lim . PMC 1892760 PMID 17592550 . Palmieri RT, Wilson MA, Iversen ES, et al. (2008). "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women" . Cancer Epidemiol. Biomarkers Prev . 17 (12): 3567–72. doi :10.1158/1055-9965.EPI-08-0548 . PMC 2664299 PMID 19064572 . Sakurai K, Migita O, Toru M, Arinami T (2002). "An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia" . Mol. Psychiatry . 7 (4): 412–5. doi :10.1038/sj.mp.4000973 PMID 11986985 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 . Whittard JD, Sakurai T, Cassella MR, et al. (2006). "MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth" . Mol. Biol. Cell . 17 (6): 2696–706. doi :10.1091/mbc.E06-01-0090 . PMC 1474804 PMID 16597699 . Angeloni D, Lindor NM, Pack S, et al. (1999). "CALL gene is haploinsufficient in a 3p- syndrome patient" (PDF) . Am. J. Med. Genet . 86 (5): 482–5. doi :10.1002/(SICI)1096-8628(19991029)86:5<482::AID-AJMG15>3.0.CO;2-L . hdl :11382/301711 PMID 10508992 .
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