MAPK7
MAPK7MAP키나제7로도 알려진 미토겐 활성 단백질 키나제7은 인간에서 MAPK7 유전자에 의해 암호화된 효소다.[5][6]
함수
MAPK7은 MAP키나제 계열이다.MAP 키나제스는 복수의 생화학적 신호의 통합점 역할을 하며 증식, 분화, 전사 규제, 개발 등 매우 다양한 세포 과정에 관여한다.이 키나제는 특히 미토겐 활성 단백질 키나제 키나제 5(MAP2K5/MEK5)에 의해 활성화된다.수용체 타이로신키나제, G단백질결합 수용체 등 다양한 수용체 분자의 다운스트림 신호 과정에 관여한다.세포외 신호에 대응하여 이 키나아제는 세포핵에 반투명하며, 여기서 인산화하여 유전자 발현을 조절하고 다른 전사 인자를 활성화시킨다.이 유전자의 네 가지 다른 분할된 대본 변형이 두 개의 뚜렷한 이소 형태를 인코딩하는 것으로 보고되었다.[7]
MAPK7은 심혈관계 발달에도 중요하며 내피세포 기능에도 필수적이다.[9][10]
상호작용
MAPK7은 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000166484 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000001034 - 앙상블, 2017년 5월
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- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ "Entrez Gene: MAPK7 mitogen-activated protein kinase 7".
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- ^ Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J (May 2003). "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation". J. Biol. Chem. 278 (20): 18682–8. doi:10.1074/jbc.M213283200. PMID 12637502.
- ^ a b Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
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- ^ Hayashi M, Tapping RI, Chao TH, Lo JF, King CC, Yang Y, Lee JD (Mar 2001). "BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase". J. Biol. Chem. 276 (12): 8631–4. doi:10.1074/jbc.C000838200. PMID 11254654.
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추가 읽기
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