Androgen Receptor Activator(ARA70)라고도 알려진 핵수용체 공동활성화제 4 는 사람에게서 NCO4 [5] [6] [7] 유전자 에 의해 암호화되는 단백질 이다. 페리티노파지에 중요한 역할을 하며, 화물 수용체 역할을 하며, 페리티닌 중쇄에 결합하고 오토파고좀의 표면에 있는 ATG8에 부착됩니다.
상호 작용 NCOA4는 다음과 상호작용하는 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000266412 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000056234 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene . 9 (2): 509–16. PMID 8290261 . ^ a b Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells" . Proceedings of the National Academy of Sciences of the United States of America . 93 (11): 5517–21. Bibcode :1996PNAS...93.5517Y . doi :10.1073/pnas.93.11.5517 PMC 39278 PMID 8643607 . ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4" .^ ^ Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells" . Proceedings of the National Academy of Sciences of the United States of America . 95 (13): 7379–84. Bibcode :1998PNAS...95.7379M . doi :10.1073/pnas.95.13.7379 PMC 22623 PMID 9636157 . ^ Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor" . Proceedings of the National Academy of Sciences of the United States of America . 98 (13): 7200–5. Bibcode :2001PNAS...98.7200L . doi :10.1073/pnas.121173298 PMC 34646 PMID 11404460 . ^ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells" . Proceedings of the National Academy of Sciences of the United States of America . 96 (10): 5458–63. Bibcode :1999PNAS...96.5458Y . doi :10.1073/pnas.96.10.5458 PMC 21881 PMID 10318905 . ^ Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)" . Molecular Endocrinology . 16 (2): 287–300. doi :10.1210/mend.16.2.0765 PMID 11818501 . ^ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators" . The Journal of Biological Chemistry . 277 (12): 10226–35. doi :10.1074/jbc.M111975200 PMID 11779876 . ^ Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays" . Molecular Endocrinology . 13 (10): 1645–56. doi :10.1210/mend.13.10.0352 PMID 10517667 . ^ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs" . Molecular and Cellular Biology . 23 (6): 2135–50. doi :10.1128/mcb.23.6.2135-2150.2003 . PMC 149467 PMID 12612084 . ^ Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma" . The Journal of Biological Chemistry . 274 (23): 16147–52. doi :10.1074/jbc.274.23.16147 PMID 10347167 . ^ Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (May 2014). "Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy" (PDF) . Nature . 509 (7498): 105–9. Bibcode :2014Natur.509..105M . doi :10.1038/nature13148 . PMC 4180099 PMID 24695223 . ^ Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, et al. (November 2014). "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo". Nature Cell Biology . 16 (11): 1069–79. doi :10.1038/ncb3053 . PMID 25327288 . S2CID 21172670 . ^ Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F (January 2016). "NCOA4 Deficiency Impairs Systemic Iron Homeostasis" . Cell Reports . 14 (3): 411–421. doi :10.1016/j.celrep.2015.12.065 PMID 26776506 . 추가 정보 Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I (September 1994). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2". Genes, Chromosomes & Cancer . 11 (1): 51–7. doi :10.1002/gcc.2870110108 . PMID 7529046 . S2CID 45815041 . Jhiang SM, Smanik PA, Mazzaferri EL (April 1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma". Cancer Letters . 78 (1–3): 69–76. doi :10.1016/0304-3835(94)90033-7 . PMID 8180971 . Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA (June 1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas". Cancer Research . 54 (11): 2979–85. PMID 8187085 . Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA (June 1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas". Genomics . 42 (2): 252–9. doi :10.1006/geno.1997.4685 . PMID 9192845 . Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells" . Proceedings of the National Academy of Sciences of the United States of America . 95 (13): 7379–84. Bibcode :1998PNAS...95.7379M . doi :10.1073/pnas.95.13.7379 PMC 22623 PMID 9636157 . Kang HY, Yeh S, Fujimoto N, Chang C (March 1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor" . The Journal of Biological Chemistry . 274 (13): 8570–6. doi :10.1074/jbc.274.13.8570 PMID 10085091 . Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells" . Proceedings of the National Academy of Sciences of the United States of America . 96 (10): 5458–63. Bibcode :1999PNAS...96.5458Y . doi :10.1073/pnas.96.10.5458 PMC 21881 PMID 10318905 . Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma" . The Journal of Biological Chemistry . 274 (23): 16147–52. doi :10.1074/jbc.274.23.16147 PMID 10347167 . Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays" . Molecular Endocrinology . 13 (10): 1645–56. doi :10.1210/mend.13.10.0352 PMID 10517667 . Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Reports . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor" . Proceedings of the National Academy of Sciences of the United States of America . 98 (13): 7200–5. Bibcode :2001PNAS...98.7200L . doi :10.1073/pnas.121173298 PMC 34646 PMID 11404460 . Basolo F, Giannini R, Monaco C, Melillo RM, Carlomagno F, Pancrazi M, Salvatore G, Chiappetta G, Pacini F, Elisei R, Miccoli P, Pinchera A, Fusco A, Santoro M (January 2002). "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma" . The American Journal of Pathology . 160 (1): 247–54. doi :10.1016/S0002-9440(10)64368-4 . PMC 1867131 PMID 11786418 . Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)" . Molecular Endocrinology . 16 (2): 287–300. doi :10.1210/mend.16.2.0765 PMID 11818501 . Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C (September 2002). "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation" . The Journal of Biological Chemistry . 277 (39): 36499–508. doi :10.1074/jbc.M202824200 PMID 12068007 .
외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.