E3 유비퀴틴-단백질 연결효소 RNF14는 RNF14 [5] [6] [7] 효소 이다.
기능. 이 유전자에 의해 암호화된 단백질은 단백질-단백질 상호작용에 관여하는 것으로 알려진 모티브인 RING 아연 손가락을 포함합니다. 이 단백질은 안드로겐 수용체(AR)와 상호작용하며 전립선에서 AR 표적 유전자 발현을 유도하는 공동활성제 역할을 할 수 있다. 이 유전자의 지배적인 음성 돌연변이는 전립선암의 AR 매개 성장을 억제하는 것으로 입증되었다. 이 단백질은 또한 클래스 III 유비퀴틴 결합 효소(E2s)와 상호작용하며 특정 핵 단백질의 유비퀴티화에서 유비퀴틴 리가아제(E3)로 작용할 수 있다. 두 개의 서로 다른 아이소폼을 코드하는 5개의 대체 스플라이스된 전사 변종이 [7] RNF14 단백질의 또 다른 기능은 생체 에너지 상태와 염증 사이의 상호 관계에 대한 조절과 관련이 있다. 그것은 사이토카인과 간섭자 조절 [8]
상호 작용 RNF14는 안드로겐 [5] [9] [10] [11] 것 으로 나타났다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000013561 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000060450 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Kang HY, Yeh S, Fujimoto N, Chang C (Apr 1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor" . J Biol Chem . 274 (13): 8570–6. doi :10.1074/jbc.274.13.8570 PMID 10085091 . ^ Ueki N, Seki N, Yano K, Masuho Y, Saito T, Muramatsu M (Jun 1999). "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif". Biochim Biophys Acta . 1445 (2): 232–6. doi :10.1016/s0167-4781(99)00045-7 . PMID 10320776 . ^ a b 엔트레스진 9604 ^ Ingham AB, Osborne SA, Menzies M, Briscoe S, Chen W, Kongsuwan K, et al. (January 2014). "RNF14 is a regulator of mitochondrial and immune function in muscle" . BMC Systems Biology . 8 : 10. doi :10.1186/1752-0509-8-10 . PMC 3906743 PMID 24472305 . ^ Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (Feb 2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth" . J. Biol. Chem . 277 (7): 4609–17. doi :10.1074/jbc.M108312200 PMID 11673464 . ^ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators" . J. Biol. Chem . 277 (12): 10226–35. doi :10.1074/jbc.M111975200 PMID 11779876 . ^ He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs" . Mol. Cell. Biol . 23 (6): 2135–50. doi :10.1128/mcb.23.6.2135-2150.2003 . PMC 149467 PMID 12612084 .
추가 정보 Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol . 16 (13): 1338–42. doi :10.1038/4315 . PMID 9853615 . S2CID 20001769 . Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8" . Eur. J. Biochem . 268 (9): 2725–32. doi :10.1046/j.1432-1327.2001.02169.x PMID 11322894 . Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth" . J. Biol. Chem . 277 (7): 4609–17. doi :10.1074/jbc.M108312200 PMID 11673464 . Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells" . J. Biol. Chem . 277 (41): 38087–94. doi :10.1074/jbc.M203313200 PMID 12163482 . He B, Wilson EM (2003). "Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs" . Mol. Cell. Biol . 23 (6): 2135–50. doi :10.1128/MCB.23.6.2135-2150.2003 . PMC 149467 PMID 12612084 . Mestayer C, Blanchère M, Jaubert F, Dufour B, Mowszowicz I (2003). "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines". Prostate . 56 (3): 192–200. doi :10.1002/pros.10229 . PMID 12772188 . S2CID 23253844 . Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Keng P, Chang C (2004). "Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells" . Mol. Cell. Biol . 24 (5): 2202–13. doi :10.1128/MCB.24.5.2202-2213.2004 . PMC 350564 PMID 14966297 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx" . Mol. Cell. Biol . 24 (24): 10529–41. doi :10.1128/MCB.24.24.10529-10541.2004 . PMC 533990 PMID 15572661 . Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, di Sant'Agnese PA, Chang C (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth" . Mol. Endocrinol . 21 (2): 343–58. doi :10.1210/me.2006-0104 PMID 17082327 . Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant'Agnese PA, Tsai MY, Chang C (2007). "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54" . Endocrinology . 148 (3): 1340–9. doi :10.1210/en.2006-0716 PMID 17110431 . Kikuchi H, Uchida C, Hattori T, Isobe T, Hiramatsu Y, Kitagawa K, Oda T, Konno H, Kitagawa M (2007). "ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells" . Carcinogenesis . 28 (8): 1752–8. doi :10.1093/carcin/bgm120 PMID 17510080 . 외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.