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CLASSIC: Ultra-high throughput mapping of genetic design space

This repository contains source code, and minimal datasets used in O'Connell*, Rai* et al (2025). The code and associated data is present in three sub-folders, one each corresponding to the three libraries demonstrated with CLASSIC. Namely -

  1. A 384-member library with diversified promoters, kozak sequences and terminators: EU_library
  2. A 166,000-member library with 10 diversified components across a 2-gene inducible circuit: Single_input_library
  3. A 3.4 billion-member library with 15 diversified components across a 3-gene dual inducible circuit: Multi_input_library

In case of any questions, or if you require any dataset or variables in addition to those provided in the repository, please contact Kshitij Rai (kshitij.rai@rice.edu) or Ronan O'Connell (ronan.oconnell3@gmail.com)

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Scripts and sample data associated with Rai & O'Connell et al (2023)

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