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DrugSeq

DrugSeq pipeline to predict drug sensitivity DrugSeq schematic

DrugSeq is available through shinyapps.io at https://combin.shinyapps.io/DrugSeq

Requirements for disease signatures file:
-use official gene symbol
-no duplicate gene symbols
-expression normalized to tissue matched control (log2 fold change)
-sample ID does not begin with number

Requirements for metadata file:
-sample ID matches with disease signature file
-sample ID and meta ID do not start with a number
-minimum of three meta groups (for ANOVA)

Test files are available at the following:
-disease signature: https://github.com/AyadLab/DrugSeq/blob/main/App/test_Cavalli_disease_signature.csv
-metadata: https://github.com/AyadLab/DrugSeq/blob/main/App/test_Cavalli_metadata.csv

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DrugSeq pipeline to predict drug sensitivity

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