Study Descriptions Amount of assay data provided from each study study aggregation binding expression immunogenicity pharmacokinetics polyreactivity thermostability license Biophysical properties of the clinical-stage antibody landscape 685 137 685 137 Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows 301 33 86 86 43 http://creativecommons.org/licenses/by-nc/4.0/ Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies 97 http://creativecommons.org/licenses/by-nc-nd/4.0/ Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis 128 http://creativecommons.org/licenses/by-nc/4.0/ Unlocking de novo antibody design with generative artificial intelligence 65 461 39 26 39 Clear BSD (https://github.com/AbSciBio/unlocking-de-novo-antibody-design/blob/main/LICENSE) Machine learning optimization of candidate antibody yields highly diverse sub-nanomolar affinity antibody libraries 3,163,629 Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License (“CC BY-NC-SA 4.0”) AbRank: A Benchmark Dataset and Metric-Learning Framework for Antibody-Antigen Affinity Ranking 342,357 https://creativecommons.org/licenses/by-nc/4.0/ Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves 11,067 10,970 https://creativecommons.org/licenses/by/4.0/ A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide 352,140 https://creativecommons.org/licenses/by/4.0/ Efficient evolution of human antibodies from general protein language models 146 37 https://creativecommons.org/licenses/by/4.0/ Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen 362 258 http://creativecommons.org/licenses/by-nc/4.0/ Retrospective SARS-CoV-2 human antibody development trajectories are largely sparse and permissive 2,276 Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding 4,276 High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface Antigens 697 https://creativecommons.org/licenses/by-nc/4.0/ Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space 444 126 https://creativecommons.org/licenses/by/4.0/ An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries 2,111 https://creativecommons.org/licenses/by/4.0/ Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies 67,035 https://creativecommons.org/licenses/by/4.0/ Ab-CoV: a curated database for binding affinity and neutralization profiles of coronavirus-related antibodies 568 Automated optimisation of solubility and conformational stability of antibodies and proteins 19 38 19 https://creativecommons.org/licenses/by/4.0/ IgDesign: In vitro validated antibody design against multiple therapeutic antigens using inverse folding 321 MIT License (https://github.com/AbSciBio/igdesign/blob/main/LICENSE) Unsupervised evolution of protein and antibody complexes with a structure-informed language model 224 39 MIT License (https://github.com/varun-shanker/structural-evolution/blob/main/LICENSE) AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions 573,892 https://creativecommons.org/licenses/by-nc/4.0/ A SARS-CoV-2 Interaction Dataset and VHH Sequence Corpus for Antibody Language Models 77,004 https://creativecommons.org/licenses/by-nc/4.0/ Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces 2,049 https://creativecommons.org/licenses/by/4.0/ Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics 21 Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves 11,067 10,970 https://creativecommons.org/licenses/by/4.0/ Humanization of antibodies using a machine learning approach on large-scale repertoire data 217 https://creativecommons.org/licenses/by/4.0/ Identifying developability risks for clinical progression of antibodies using high-throughput in vitro and in silico approaches 132 1,022 https://creativecommons.org/licenses/by-nc/4.0/ Assisted Design of Antibody and Protein Therapeutics (ADAPT) 33 https://creativecommons.org/licenses/by/4.0/ NbThermo: a new thermostability database for nanobodies 673 https://creativecommons.org/licenses/by/4.0/