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Spec-driven development (SDD) for AI coding assistants.

TypeScript 48,598 3,407 Updated May 14, 2026

Blazing-Fast Bioinformatic Operations on Python DataFrames

Python 161 32 Updated May 17, 2026

Rust (de)serialization for the Python pickle format.

Rust 2 1 Updated Apr 9, 2026

NOT MAINTAINED - A simple Rust like Result type for Python 3. Fully type annotated.

Python 1,691 90 Updated Aug 19, 2024

High-performance UMI tools for NGS data analysis

Rust 45 2 Updated May 16, 2026

A high-performance antibody and TCR sequence numbering tool for Rust, Python, Polars and JS/TS.

Rust 28 3 Updated Apr 30, 2026

Fastest pure Rust implementation of LZ4 compression/decompression.

Rust 596 48 Updated May 17, 2026

A Rust reimplementation of PyMOL molecular visualization

Rust 112 6 Updated Apr 16, 2026

A scientific plotting library in Rust

Rust 754 29 Updated May 14, 2026

MLX: An array framework for Apple silicon

C++ 26,275 1,806 Updated May 14, 2026

🐰 Bencher - Continuous Benchmarking

Rust 840 40 Updated May 17, 2026

Command-line sampling profiler for macOS, Linux, and Windows

Rust 4,197 98 Updated May 13, 2026

Perpetual is a high-performance gradient boosting machine. It delivers optimal accuracy in a single run without complex tuning through a simple budget parameter. It features out-of-the-box support …

Rust 680 39 Updated Apr 2, 2026

A SMILES parser based on Purr

Rust 11 1 Updated Mar 26, 2026

Open Source Research Claw

TypeScript 775 36 Updated May 13, 2026

job-ops: DevOps principles applied to job hunting. A self-hosted pipeline to track, analyze, and assist your application process

TypeScript 3,124 375 Updated May 15, 2026

🐹 Deep clean and optimize your Mac.

Shell 51,632 1,620 Updated May 17, 2026

Rust implementation of Needleman-Wunsch & Smith-Waterman sequence alignment

Rust 22 6 Updated Jun 25, 2025

Up to 100x faster strings for C, C++, CUDA, Python, Rust, Swift, JS, & Go, leveraging NEON, AVX2, AVX-512, SVE, GPGPU, & SWAR to accelerate search, hashing, sorting, edit distances, sketches, and m…

C 3,453 125 Updated May 5, 2026

Fast SQL formatter/linter

Rust 1,305 60 Updated May 17, 2026

Fast tokenizer for language models, compatible with SentencePiece, Tokenizers, Tiktoken and more. Supports BPE, Unigram and WordPiece tokenization in JavaScript, Python and Rust.

Rust 49 2 Updated May 10, 2026

Fast approximate string searching

Rust 126 10 Updated May 12, 2026

Learned diffusion heuristics with GPU-accelerated search for short paths in large graphs.

Python 68 7 Updated Nov 9, 2025

A simplified implementation of DSSP algorithm for PyTorch and NumPy

Python 103 14 Updated Jun 9, 2025

A data modelling layer built on top of polars and pydantic

Python 627 29 Updated May 8, 2026

Intuitive find & replace CLI (sed alternative)

Rust 7,126 160 Updated Feb 25, 2026

Bioinformatics I/O libraries in Rust

Rust 695 74 Updated May 6, 2026

A fast TOML library for python implemented in rust.

Python 400 30 Updated Oct 19, 2025

🐍 Scan your Python dependencies for known security vulnerabilities with Rust-powered scanner

Rust 238 9 Updated Apr 14, 2026

Awesome papers related to generative flow matching and its applications in bioinformatics. (Nature Machine Intelligence)

41 6 Updated Apr 24, 2026
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