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Starred repositories

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the simple alchemistry test set

Python 10 13 Updated Nov 20, 2025

Full automation of relative protein-ligand binding free energy calculations in GROMACS

Python 46 15 Updated May 3, 2021

Protein-Ligand Benchmark Dataset for Free Energy Calculations

Python 211 18 Updated Jul 29, 2024

The Open Free Energy toolkit

Python 224 35 Updated Dec 24, 2025

An open tool implementing some recommended practices for analyzing alchemical free energy calculations

Python 134 62 Updated May 24, 2024

Inputs, results, and pipeline code for Modular and Interoperable Workflows for Benchmarking Alchemical Binding Free Energy Calculation Methodologies manuscript.

Jupyter Notebook 9 1 Updated Nov 24, 2025
TeX 4 Updated Dec 15, 2017

A tutorials suite for BioSimSpace.

Jupyter Notebook 31 7 Updated Oct 22, 2025

Topology Superimposition based on joint graph traversal

Python 9 1 Updated Dec 22, 2025

An interoperable Python framework for biomolecular simulation.

Python 139 19 Updated Dec 16, 2025

Automated Adaptive Absolute alchemical Free Energy calculator

Python 113 14 Updated Oct 21, 2025

PyAutoFEP: an automated FEP workflow for GROMACS integrating enhanced sampling methods

Python 201 81 Updated Sep 22, 2023

The Binding Affinity Tool (BAT.py) is a fully automated tool for absolute binding free energy (ABFE) and relative binding free energy (RBFE) calculations on protein-ligand systems, compatible with …

Python 217 51 Updated Nov 23, 2025
Python 16 9 Updated Dec 24, 2016

OpenMM-based framework for absolute and relative binding free energy calculations with the Alchemical Transfer Method

Python 145 38 Updated Dec 8, 2025

Build coarse-grained mapping for molecules from a web-GUI

JavaScript 15 4 Updated Sep 10, 2021

Tools for coarse-grained molecular dynamics simulations using the SPICA force field

Python 13 6 Updated Apr 11, 2025

Wrappers around NIST REFPROP for languages such as Python, MATLAB, etc.

Mathematica 234 135 Updated Sep 23, 2025

Converters to go to/from other fluid file formats

C++ 3 2 Updated Feb 4, 2025

teqp-based thermodynamic mixture model optimization

Python 11 4 Updated Dec 19, 2024

The python code for fitting interaction parameters for binary mixtures

Python 10 Updated Dec 11, 2024

GROMACS implementation of TraPPE-UA force field with HH-Alkane modifications

13 6 Updated Sep 24, 2022

Python for chemoinformatics

Jupyter Notebook 231 91 Updated Jun 26, 2021

A conda-forge distribution.

Shell 9,048 461 Updated Dec 6, 2025

Efficient and easy to use fortran implementation of the Ewald summation method

Fortran 19 Updated Jun 27, 2023

A Package for Parametrization of Molecular Mechanics Force Fields

Python 32 4 Updated Nov 13, 2022

Scripts for calculating RESP charges with Gaussian, starting only with .xyz file of your compound. Generate .mol2, .frcmod and .pdb with calculated RESP charges, for Molecular Dynamic simulations i…

Shell 9 2 Updated Mar 26, 2019

Automated Backward and Forward Selection On Python

Python 67 21 Updated Nov 12, 2020

Tensorflow port of Image-to-Image Translation with Conditional Adversarial Nets https://phillipi.github.io/pix2pix/

JavaScript 5,092 1,293 Updated Feb 2, 2021

A Pytorch implementation of Pix2Pix GAN

Python 33 5 Updated Jul 15, 2021
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