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Implement a ChatGPT-like LLM in PyTorch from scratch, step by step

Jupyter Notebook 81,389 12,164 Updated Dec 21, 2025

AGENTS.md — a simple, open format for guiding coding agents

TypeScript 12,757 920 Updated Dec 19, 2025

💫 Industrial-strength Natural Language Processing (NLP) in Python

Python 32,973 4,631 Updated Nov 27, 2025
Jupyter Notebook 736 149 Updated Dec 18, 2025

The best ChatGPT that $100 can buy.

Python 38,964 4,928 Updated Dec 9, 2025

Share, discover, and collect prompts from the community. Free and open source — self-host for your organization with complete privacy.

TypeScript 139,995 18,570 Updated Dec 21, 2025

Evals is a framework for evaluating LLMs and LLM systems, and an open-source registry of benchmarks.

Python 17,446 2,853 Updated Nov 3, 2025

LLM prompts for structured software development because quality takes more than just "good vibes".

83 6 Updated Jun 12, 2025

An automatic evaluator for instruction-following language models. Human-validated, high-quality, cheap, and fast.

Jupyter Notebook 1,925 295 Updated Aug 9, 2025

💫 Toolkit to help you get started with Spec-Driven Development

Python 56,765 4,942 Updated Dec 4, 2025

Runnable algo template for trading the Options Wheel strategy

Python 92 29 Updated Jun 5, 2025

Lightweight coding agent that runs in your terminal

Rust 54,388 6,904 Updated Dec 21, 2025

tiktoken is a fast BPE tokeniser for use with OpenAI's models.

Python 16,817 1,342 Updated Oct 6, 2025

Supercharge Your LLM Application Evaluations 🚀

Python 11,798 1,178 Updated Dec 20, 2025

The OpenAI Model Spec

710 83 Updated Dec 18, 2025

Trainable, memory-efficient, and GPU-friendly PyTorch reproduction of AlphaFold 2

Python 3,227 646 Updated Dec 16, 2025

FoldFlow: SE(3)-Stochastic Flow Matching for Protein Backbone Generation

Jupyter Notebook 271 23 Updated Dec 10, 2024

Tools making use of BiopLib

C 18 7 Updated Nov 21, 2025

Software Foundations

HTML 149 36 Updated Apr 30, 2024

DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data.

Python 3,577 770 Updated Oct 21, 2025

Genome annotation with AUGUSTUS

C++ 322 116 Updated Aug 15, 2025

A versatile pairwise aligner for genomic and spliced nucleotide sequences

C 2,094 448 Updated Dec 12, 2025

Burrow-Wheeler Aligner for short-read alignment (see minimap2 for long-read alignment)

C 1,683 568 Updated Mar 22, 2025

Metaprogramming, verified meta-theory and implementation of Rocq in Rocq

Rocq Prover 493 96 Updated Dec 19, 2025

Specifications of SAM/BAM and related high-throughput sequencing file formats

TeX 691 179 Updated Nov 4, 2025

C library for high-throughput sequencing data formats

C 895 459 Updated Dec 19, 2025

This is the development home of the workflow management system Snakemake. For general information, see

Python 2,663 617 Updated Dec 20, 2025

A DSL for data-driven computational pipelines

Groovy 3,242 753 Updated Dec 20, 2025

The Z3 Theorem Prover

C++ 11,726 1,588 Updated Dec 20, 2025

Homomer symmetry prediction from protein sequence

Python 39 7 Updated Mar 13, 2025
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