A ModelsCloud wrapper for the ACCEPT package — ACute COPD Exacerbation Prediction Tool.

This package wraps the resplab/accept package for deployment on the ModelsCloud platform. It supports all versions of ACCEPT including ACCEPT 3.0-CPRD, a UK primary-care specific recalibration derived from the Clinical Practice Research Datalink (CPRD).

For direct use, install the main ACCEPT package instead:

remotes::install_github("resplab/accept")

• ACCEPT 3.0-CPRD (country = "GBR-primary") — UK primary care recalibration using CPRD data. Includes automatic imputation of missing optional predictors.
• ACCEPT 3.0 (version = "accept3") — Country-specific recalibration based on the NOVELTY study. Requires a country code.
• ACCEPT 2.0 (version = "accept2") — Updated model improving accuracy for patients without exacerbation history.
• ACCEPT 1.0 (version = "accept1") — Original ACCEPT model.

When using country = "GBR-primary", these predictors are optional — if missing they are automatically imputed using a UK-specific sequential regression imputation model derived from CPRD data:

LABA, oxygen, ICS, LAMA, statin, BMI, smoker

For all other versions, all predictors should be provided. For requirements for other versions, see resplab/accept.

library(modelscloud)
connect_to_model("resplab/acceptpexa", access_key = "YOUR_API_KEY")

# Get sample patients
patients <- get_sample_input()

# UK primary care - ACCEPT 3.0-CPRD (all predictors present)
model_run(patients, country = "GBR-primary")

# UK primary care - with missing optional predictors (auto-imputed)
patients_missing <- patients
patients_missing$BMI    <- NULL
patients_missing$statin <- NULL
patients_missing$LABA   <- NULL
model_run(patients_missing, country = "GBR-primary")

# UK specialty care
model_run(patients, country = "GBR-specialty")

# Other countries (ACCEPT 3.0)
model_run(patients, country = "CAN")
model_run(patients, country = "USA")

# ACCEPT 2.0
model_run(patients, version = "accept2")

# ACCEPT 1.0
model_run(patients, version = "accept1")

# Single patient
model_run(get_default_input(), country = "GBR-primary")

ARG, AUS, BRA, CAN, COL, DEU, DNK, ESP, FRA, ITA, JPN, KOR, MEX, NLD, NOR, SWE, USA

For UK: use "GBR-primary" (primary care) or "GBR-specialty" (specialty care).

For unsupported countries, provide obs_modsev_risk:

model_run(patients, version = "accept3", country = "XXX", obs_modsev_risk = 0.2)

• resplab/accept — main ACCEPT package
• resplab/accept3_UK — manuscript analysis code
• ModelsCloud platform