htslib

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pysam-developers / pysam

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

python bioinformatics ngs htslib

Updated Apr 12, 2026
Cython

brentp / cyvcf2

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cython + htslib == fast VCF and BCF processing

bioinformatics genomics cython vcf htslib

Updated Feb 23, 2026
Cython

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