Utility functions for modelling and simulation workflows within esqLABS organization

The physiologically-based whole-body model of the glucose-insulin-glucagon regulatory system

Umbrella repo for the ToxMCP Suite (docs, links, quickstart).

Physiologically Based Pharmacokinetic Models for Pregnant Women

Implementation of inhalation model in MoBi

MCSim Models in R

Open access PBPK modelling platform

Create diagrams with ggplot.

Whole-body PBPK model of digoxin as P-gp DDI victim drug

A Quantitative Systems Pharmacology kidney model of diabetes associated renal hyperfiltration and the effects of SGLT inhibitors.

Whole-body PBPK model of Vancomycin

Antimony/SBML re-implementation of the EuroMix Generic PBK model.

Code for the paper "A Combination of Machine Learning and PBPK Modeling Approach for Pharmacokinetics Prediction of Small Molecules in Humans"

Physiology-based systems pharmacology model of thyroid hormones regulation in rat and human

MCP server for PBPK modeling workflows (simulation control + PK analytics).

Whole-body PBPK model of voriconazole as CYP2C19 substrate and CYP3A4 perpetrator drug

An effort to reproduce the Geerts 2022 PBPK/QSP model with SBML and python. References: Geerts H, Walker M, Rose R, et al. A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease. CPT Pharmacometrics Syst Pharmacol. 2023; 12: 444-461. doi:10.1002/psp4.1291

Cabozantinib PBPK