At the Department of Anaesthesiology and Intensive Care of the University Medicine Greifswald we investigate the recapture/recycling rate of ZeoSys's CONTRAfluran carbon filter/vapour capture technology at two Draeger Perseus A500 anaesthesia machines.

This repository contains the (raw) data and analysis of this investigation.

Gibb, S., Möller, N., von Dincklage, F. and Knigge, S. Capture efficiency of CONTRAfluran^TM absorbers for sevoflurane in routine anaesthesia practice: a prospective observational single-center study. BMC Anesthesiol 25, 600 (2025). https://doi.org/10.1186/s12871-025-03491-3

• data: cleaned and summarized data for each anaesthetic gas canister, see data/README.md for details.
• raw-data: raw Draeger connect, CONTRAfluran and Sevoflurane weight measurements, see raw-data/README.md for details.

• manuscript.Rmd: main file (contains manuscript and author information) loading all subsections.
• sections/*.Rmd: a file per subsection containing the manuscript content.

• guix/: guix releated files to ensure a reproducible R and pandoc environment.
• bibliography/: references in bibtex format.
• pandoc/: pandoc related files for word counts etc.

Initially we used sevoflurane usage data logged by "Dräger connect" in the assumption it was reading the D-Vapor 3000 dial settings and fresh gas flows. The data from "Dräger connect" were estimated based on the flow and the inspiratory/endtidal sevoflurane concentration. While the measurements are reasonably for Dräger Primus anaesthesia machines (see Biro et al. 2014) we restart our study and weigh the sevoflurane bottles to determine the amount of used agent.

We use guix to ensure an reproducible computing environment.

sudo apt install make git guix

git clone git@github.com:umg-minai/vct-or.git

Running make the first time will take some time because guix hast to download the given state and build the image.

make

All the work has to be done in the sections/*.Rmd files.

• make or make manuscript produces an .html file in output/.
• make dist produces a .docx in distribute/ which could be send to the co-authors.
• make validate for data validation.
• make gh-pages updates the gh-pages branch to the latest manuscript.
• make clean removes all generated files.

You are welcome to:

• submit suggestions and bug-reports at: https://github.com/umg-minai/vct-or/issues
• send a pull request on: https://github.com/umg-minai/vct-or/
• compose an e-mail to: mail@sebastiangibb.de

We try to follow:

• Conventional Commits
• Semantic Line Breaks