A group of researchers for a pharmaceutical company release Gleemonex, a drug that brings people's happiest memory to the surface and cures depression. All is right in the world, at least until the drug is discovered to have some side effects down the road.
The Kids in the Hall had a great show, and it's no surprise they were able to make a great movie. With a very limited cast, they play dozens of parts and keep the humor rolling from the very beginning. If there's a group that is the spiritual successor to Monty Python, it is probably KITH.
Some of the best jokes are just throw-aways: a cop that dreams about sex with toast, a therapist who doesn't speak German, and a scientist who develops a drug that gives ex-girlfriends worms. One of the running jokes throughout the film is a man who is obviously gay but is unable to admit it. He is consistently funny, even after he comes out in the middle of a musical scene.
Some people allegedly thought that including Cancer Boy was insensitive and not funny in the slightest. I disagree. If it's okay to make fun of depression and homosexuals, I think cancer should be perfectly acceptable. I may not be easily offended, but I think this was fine.
A couple other things made this film great: a great soundtrack with bands like They Might Be Giants and The Odds. One of the earliest film appearances of Selma Blair. Seriously, the only way you would not find this funny is if you had a stick up your butt or you were a flipper baby.
