Pickett was born March 18, 1941 in Prattville, Alabama and grew up singing in Baptist church choirs.
He was the fourth of 11 children and called his mother "the baddest woman in my book," telling historian Gerri Hirshey: "I get scared of her now. She used to hit me with anything, skillets, stove wood — (one time I ran away and) cried for a week. Stayed in the woods, me and my little dog." Pickett eventually left to live with his father in Detroit in 1955.
Pickett's Atlantic career began with a self-produced single, "I'm Gonna Cry". Looking to boost Pickett's chart chances, Atlantic next paired him with record producer Bert Berns and established songwriters Barry Mann and Cynthia Weil. With this team, Pickett recorded "Come Home Baby," a duet with singer Tami Lynn, but this single failed to chart.
Pickett's breakthrough came at Stax Records' recording studio in Memphis, Tennessee, where he recorded his third Atlantic single,