IMMUNOHEMATOLOGY- UNIT 1 EXAM

Please provide the correct answer.

In ABO HDN the first child could be affected *

True
False

Which of the following is considered as disadvantage of Perfluorochemicals? *

Deep freezed storage temperatures
Adverse clinical effects
Biological Inertness
Very stable
High Oxygen affinity
Increased oncotic effect
Short intravascular half-life
Retention in tissues

Amniocentesis is a procedure employed when testing for the following , EXCPET: *

direct Antniglobulin Test
Fetal hemoglobin
Neonatal Hematocrit
Fetal blood typing
All of the choices

All of the following are true of exchange transfusion, EXCEPT; *

Suppresion of erythropiesis
Removal of part of circulating maternal antigens
Removal of sensitized RBC's
Repalcement of incompatible RBC's with compatible RBC's

The antigen production of Lewis depends on the following ,EXCEPT: *

None of the choices
Inheritance of the Le gene
Inheritance of the Se gene
Inheritance of the Hh gene

Where is the location of glycolipid? *

Cytoplasm
RBC cell membrane
Nucleoplasm

Which immunoglobulin reacts at 21 deg. celsius? *

IgG
IgA
IgM wa koy sure
IgD
An Rh nomenclature which codes for the presence or the absence of the given antigen *
ISBT terminology
Fisher-Race terminology
Wiener Terminology
Rosenfield terminology

What is the composition of 3% washed RBC suspension? *

RBC < Saline Solution w/o interfering substances
Saline Solution > RBC w/ 3% extracellular proteins
RBC > Saline Solution w/ 5% extracellular proteins
Saline Solution < RBC w/o interfering substances

What do you call the study of inheritance or the transmission of characteristics from
parents to offspring. *
Immunohematology
Immunogenetics
Genetics
Haploid Genetics

Identified as the person who donates blood in exchange for money or favors: *
Family Replacement Blood donor
Paid/Professional donor
Non-remunerated blood donor
Autologous donor

The chromosomal location of Lewis gene *

9
19
1
2

A description of which antigens are present on an individual’s RBCs and simply indicates
the results of serologic tests on those RBCs. *
Gene
Allele
Antigen
Antibody

Crossing over of antigens of most blood group system is common *

True
False

True of ABO HDN *

Lily's graph at Zone III
Jaundice peaks immediately after birth
Severe anemia = rare
Hemoglobin significantly decrease

Which of the following immunoglobulin reacts best at 37 deg. celsius? *

N antigen
Anti-N
IgM

What is the Fisher-Race equivalent of Rho rh' hr"/rh' rh" blood factor? *
DCe/dCE
DCe/DCE
DCE/DCE
DCe/dCe

Lewis enzyme has been detected in the following ,EXCEPT: *

Pancreas
Milk
Kidney
Saliva

What method is performed in preventing hemolytic transfusion reaction which can be

caused by antibodies of the ABO blood group antigens? *
Antibody screening
Crossmatching
Blood typing
Compatibility testing

ABO HDN is usually diagnosed pre-delivery *

False
True

The only antibody that can cross the placenta causing HDN *
IgG2
IgG3
IgM
IgA

Which of the following hydrocarbon structures replaces hydrogen to fluorine and is able
to deliver oxygen to tissues inaccessible to RBCs? *
Perfluorocarbons
Chlorofluorocarbons
All of the above because they contain carbon atoms.
Hydrofluorocarbons
Which characteristic of an antigen describes the molecular weight and its size and
appearance? *
Chemical composition
Charge
Size
Digestability

1st use of sodium citrate for transfusion: *

anticoagulant solution
None of the Above
Hustin
1914

Reactivity to 37 degree celsius: *

Yes
No
For confirmation thru dilution
Few
Some
Rare
Lub Some --- MOSTLY REACT
Fya Yes
Lua No
N Yes
Fyb Yes
M No
An investigator who was able to discover the Rh Blood group system *
Rosenfield and Lansteiner
Karl Lansteiner and Alexander Wiener
Landsteiner and Coomb's
Ronald Fisher and R. Wiener

Which of the following refers to RBC Substitutes? *

AOC
PFCs
HBOCs
All of the Above

What do you call a system that provides a standardized numeric system for naming
antigen suitable for electronic data processing equipment? *
ISBTs
PSP
ASCPi
OSHA
ISBT

IgG
IgA
IgM
IgE
IgD
180 kD - IgD
Mu Heavy Chain - IgM
19 sedimentation coefficient - IgM
21 days half-life - IgG
5.1 days half-life - IgM
7 sedimentation coefficient - IgD
Epsilon Heavy chain - IgE
Alpha Heavy Chain - IgA
900 kD - IgM
Slight reactivity in complement fixation - IgG
160-500 kD - IgA
No heavy chain allotypes – IgD/E/M
very strong reactivity agglutination in saline -IgM
Delta Heavy Chain - IgD
Able for placental transfer – IgG
180 kD - IgD
Mu Heavy Chain - IgM
19 sedimentation coefficient - IgM
21 days half-life - IgG
5.1 days half-life - IgM
7 sedimentation coefficient - IgD
Epsilon Heavy chain - IgE
Alpha Heavy Chain - IgA
900 kD - IgM
Slight reactivity in complement fixation - IgG
160-500 kD - IgA
No heavy chain allotypes – IgD/E/M
very strong reactivity agglutination in saline -IgM
Delta Heavy Chain - IgD
Able for placental transfer - IgG

Lewis antigen are found i nthe following, EXCEPT: *

Intestine
Gastric mucosa
Stomach
Adrenal glands

What is Fisher-Race System? *

produces blood factors dependent on the gene of each locus in the chromosome and each factor
has its corresponding nomenclature.
a possessed gene that expresses and control its same product.
states that there are three factors produced from a single agglutinogen.

A test used to quantitate the number of fetal RH-positive cells in the mothers circulation
as a result of a fetomaternal hemorrhage *
DAT test
Neither
Kleihauer-Betke test

Rhorh'rh" is represented by what gene * DCE (Rz) and CE (ry)

Ry
All of the choices
ry
Rz

Which of the following statement is incorrect *

antigen, D is the most antigenic
Fetomaternal hemorrhage can cause significant increase in maternal antibody titers, leading to
severity of HDN
In Rh HDN, the Rh negative infant of an Rh positive mother is unaffected
In ABO HDN, the second is usually most affected, specially if the first child is RH positive

What is the standard preservative for blood storage: *

Freezing temperature; CPD
ACD
CPD
Refrigeration; CPD

Who is Dr. Charles Drew? *

ALL of the Above
American Red Cross blood bank director (Assistant Director)
pioneering to development of techniques in blood transfusion and blood preservation led to
widespread systems of blood banks.
Director of blood bank in Presbyterian Hospital (Train/Resident)

Blood Group O individuals: *

back type: 0+; front type: 2+
back type: 3+; front type: 1+
back type: 4+; front type: 0
back type: 4+; front type: 3+
Postulated that there are specific genes of the system closely linked to set of alleles, each gene
is responsible for producing each corresponding antigen. *
Rosenfield
Fisher-Race
Wiener

In Rh HDN the first born infant is usually affected. *

False
True

What is the ideal pH for antigen-antibody reactions? *

7.0
6.0
8.0
9.0

Which of the following discoveries resulted in multiple transfusions? *

Kell System
Yt System
Xg System
MNS System

Which of the following statement best describes polyclonal antibodies? *

contains antibody to IgG and C3d component of complement.
specified for IgG and fragments of C3 complement.
contains several and mixed antibodies from clones of plasma cells and recognizes different
epitopes.
contains antibodies specific for IgG or C3 component of human complement.

What agglutinogen is responsible for HDFN? *

All of the Above
IgG3
IgG2
IgG4

Weak D antigen which denotes that antigen is present but appears to be incomplete in
numbers *
Partial D
Genetic Weak D
D mosaic
C trans
Which of the following is a method of creating RBCs in laboratories? *
Blood Culture
Blood letting
Blood Substitution
Blood Pharming

What is an RBC Substitute? *

developed to carry out safe blood transfusion to patients.
carries oxygen and proven to alleviate shortage of blood.
Either
Neither

A variation of weak D which is otherwise known as "the gene interaction effect" *

C trans
Partial D
D mosaic
Genetic weak D

Rh:1,-2,3,4,-5 has a blood factor equivalent of? *

Rhorh'hr"/Rhohr'rh"
RHo, rh'rh"/ rh'rh"
Rho,hr'hr"/hr'rh"
Rho hr'rh"/hr'rh"

Which of the following statement is correct; *

Intrauterine transfusion is necessary when amniotic fluid OD at 450 nm results are high in zone 1
Intrauterine transfusion may cause brady cardia
serologic testing in cases of HDN includes IAT
Early delivery is permitted when Lily's graph is at zone II

The genetically independent Sese, ABO Hh and Le genes are intimately associated in the
formation of? *
Le(a-b-)
Le(a+b+)
Le(a+b-)
Le(a-b+)

Which of the following is antithetical? *

Dia/ Dib
M+N- and S+
P and anti-P1

How many Kell antigen is present when there is Xk deficiency? *

440 amino acids
731 amino acids
220 amino acids
None of the above

All are true of Lewis system, EXCEPT: *

Le(a-b-) from infants erythrocytes can be transformed into Lr(a+b-) in 10 days,
Person who are Le(a-b+) do not make anti-Lea
Only Le(a+b-) is present in the saliva of a newborn infant
Lewis antigen are generally produced by Le(a-b-) individuals

Which of the following statement is true of Lewis system *

All of the above
The inheritance of Le gene acts in competition to the H gene
Individuals possessing Le gene codes for the specific glucosyltransferase enzyme
The amount of Lewis antigen detectable on the RBC is influenced by the ABO gene inherited

Which of the following laboratory procedures increases the agglutination reaction of cells
upon mixing with regaents? *
Incubation
Centrifugation
Titer
Dilution

ALL but one is not true about Lewis blood group system: *
Anti-kell antibodies are influenced by production of lewis antigen.
The amount of lewis antibodies are influenced by the inherited genes produced by ABO system.
Lewis antigens do not to be detected in RBCs.
None of the above

Lewis antibodies are rarely expressed at birth. *

True
False

Which of the following is considered as advantage of Perfluorochemicals? *

Easily synthesized
Long Shelf-life
Biological Inertness
Very stable
Increased Oxygen affinity
Increased oncotic effect
Short intravascular half-life
Lack of immunogenecity

Match the correct answer *

> concentration on group O individuals
inheritance of hh genotype
formed by placing N-acetyl-D-galactosamine carbohydrate
Discovered ABO blood group system
H Antigen> concentration on group O individuals
Bombay inheritance of hh genotype
Karl Landsteiner Discovered ABO blood group system
A1 Antigen formed by placing N-acetyl-D-galactosamine carbohydrate

What is the equivalent of dce/DcE in Rosenfiel terminology *

Rho: -1, -2, -3, 4, 5
Rho: -1, -2, 3, 4, 5
Rho: 1,-2, -3, 4 , 5
Rho: 1, - 2, 3, 4, 5

Match the Blood Anticoagulant with its storage time: *

-21 days
33 days
20 days
19 days
Acid Citrate Dextrose (Formula A) -21 days
Citrate Phosphate Dextrose – 21 days
Citrate phosphate double dextrose – 21 days
Citrate phosphate dextrose adenine – 33 days
Of the following, which is the most dangerous complications of HDFN *
Kernicterus
Hydrops fetalis
Anemia
Hemolysis

What year did the 1st transfusion of blood happened? *

1294
1924
1492
1913

Referred to as type 2 isomers of le(a+b-) 2,5,13 *

Le y
Le x
Le d
Le c

Rhogam should be administered? *

Only after the birth of the second child
72 hours after delivery
15 mL in every 45 mL blood
72 hours before delivery
______ is secreted regardless of the secretor status *
Le(a+b-)
Le (a+b+)
Le(a-b+)
Le(a-b-)

A Lil's graph illustration which usually tells severe & often life-threatening hemolysis
and requires intervention *
Zone III
Zone IV
Zone II
Zone I

Antibody titer in itself can not predict the severity of HDN *

False
True

What is the ISBT number of D antigen *

004001
002002
002001
004002

Which immunoglobulin reacts at 37.3 deg. celsius? *

IgG
IgM
IgA
IgD

d antigen is capable of causing HDN *

True
False