CCL4

CCL4L1
사용 가능한 구조물
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	1HUM, 1HUN, 1JE4, 2FK, 2FIN, 2X6L, 3TN2, 4RAL
식별자
별칭	CCL4L1, AT744.2, CCL4L, LAG-1, LAG1, SCYA4L, SCY4L1, MIP-1-베타, SCYA4L2, C-C 모티브 케모킨 리간드 4는 1과 같다.
외부 ID	OMIM: 603782 GeneCard: CCL4L1
유전자 온톨로지
분자함수	화학 작용; 사이토카인 활동; GO:0001948 단백질 결합; CCR 케모킨 수용체 결합; CCR5 케모킨 수용체 결합; CCR1 케모킨 수용체 결합; 동일한 단백질 결합;
셀룰러 컴포넌트	세포외 지역; 세포외 공간;
생물학적 과정	림프구 화학적 축; 화학 매개 신호 경로; 종양 괴사 인자에 대한 세포 반응; G 단백질 결합 수용체 신호 경로; GO:0032320, GO:00321, GO:0032855, GO:0043089, GTPase 활동에 대한 GO:0032854 양성 규제; 화학적 축; 염증 반응; 인터루킨-1에 대한 세포 반응; 단모세포 화학적; 중성미자 화학 약품; 면역 반응; ERK1 및 ERK2 계단식 규제; 인터페론 검출기에 대한 세포 반응; 신호 수용체 활성 조절; 어시노필 화학약; 칼슘 매개 신호의 양성 조절; 자연적 살인세포 화학적 작용에 대한 양성적 규제; 세포 세포 신호; 바이러스에 대한 대응; 세포 극성의 확립 또는 유지; 세포 접착; 독성 물질에 대한 반응; 신호 전달; 칼슘 이온 수송의 양성 조절; 사이토카인 매개 신호 경로;
	출처:아미고 / 퀵고
직교체
	388372
	n/a
	n/a
	n/a
	Q8NHW4; P13236
	n/a
	NM_207007
	n/a
	NP_996890; NP_002975
	n/a
	위키다타
인간 보기/편집

CCL4라고도 알려진 Chemokine (C-C 모티브) 리간즈 4는 인간에게 CCL4 유전자에 의해 암호화된 단백질이다.^[2]

함수

CCL4는 맥크로피지 염증성 단백질-1β(MIP-1β)로도 알려져 있으며 CCR5 수용체에 대한 특수성을 가진 CC 케모카인이다.그것은 자연적인 킬러 세포, 단세포 그리고 다양한 다른 면역 세포들을 위한 화학 물질이다.^[3]

CCL4는 CD8+T세포에 의해 생성되는 주요 HIV 억제 요인이다.^[4]

일반적으로 MIP-1-베타를 합성하는 천공 저메모리 CD8+T 셀.^[5]

CCL4는 중성미자, 단세포, B세포, T세포, 섬유소, 내피세포, 상피세포에 의해 생성된다.^[6]

이 케모킨의 농도는 MicroRNA-125b와 반비례하는 것으로 나타났다.체내 CCL4 농도는 나이가 들수록 높아져 만성 염증과 간 손상을 일으킬 수 있다.^[6]^[7]

상호작용

CCL4는 CCL3와 상호작용하는 것으로 나타났다.^[8]

CCL4는 G 단백질 결합 수용체 CCR5와 CCR8에 결합된다.^[6]

참고 항목

대식세포 염증 단백질

참조

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nature Immunology. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. S2CID 7901253.
^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. Bibcode:1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID 8525373. S2CID 84062618.
^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 9283–8. Bibcode:2001PNAS...98.9283K. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920.
^ ^a ^b ^c Morrison MD, Lundquist PG (April 1974). "Labyrinthine morphology and temperature in cryosurgery (guinea pig)". Acta Oto-Laryngologica. 77 (4): 261–73. doi:10.1111/acel.12294. PMC 4364832. PMID 25620312.
^ Morimoto T, Takagi H, Kondo T (January 1985). "Canine pancreatic allotransplantation with duodenum (pancreaticoduodenal transplantation) using cyclosporin A". Nagoya Journal of Medical Science. 47 (1–2): 57–66. PMID 3887178.
^ Guan E, Wang J, Norcross MA (April 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

추가 읽기

Menten P, Wuyts A, Van Damme J (December 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (April 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
Conti L, Fantuzzi L, Del Cornò M, Belardelli F, Gessani S (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
Zhao RY, Elder RT (March 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (April 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
King JE, Eugenin EA, Buckner CM, Berman JW (April 2006). "HIV tat and neurotoxicity". Microbes and Infection. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
Napolitano M, Modi WS, Cevario SJ, Gnarra JR, Seuanez HN, Leonard WJ (September 1991). "The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization". The Journal of Biological Chemistry. 266 (26): 17531–6. doi:10.1016/S0021-9258(19)47404-8. PMID 1894635.
Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
Baixeras E, Roman-Roman S, Jitsukawa S, Genevee C, Mechiche S, Viegas-Pequignot E, Hercend T, Triebel F (November 1990). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Molecular Immunology. 27 (11): 1091–102. doi:10.1016/0161-5890(90)90097-J. PMID 2247088.
Lipes MA, Napolitano M, Jeang KT, Chang NT, Leonard WJ (December 1988). "Identification, cloning, and characterization of an immune activation gene". Proceedings of the National Academy of Sciences of the United States of America. 85 (24): 9704–8. Bibcode:1988PNAS...85.9704L. doi:10.1073/pnas.85.24.9704. PMC 282843. PMID 2462251.
Brown KD, Zurawski SM, Mosmann TR, Zurawski G (January 1989). "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes". Journal of Immunology. 142 (2): 679–87. PMID 2521353.
Zipfel PF, Balke J, Irving SG, Kelly K, Siebenlist U (March 1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors". Journal of Immunology. 142 (5): 1582–90. PMID 2521882.
Chang HC, Reinherz EL (June 1989). "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes". European Journal of Immunology. 19 (6): 1045–51. doi:10.1002/eji.1830190614. PMID 2568930. S2CID 35270650.
Miller MD, Hata S, De Waal Malefyt R, Krangel MS (November 1989). "A novel polypeptide secreted by activated human T lymphocytes". Journal of Immunology. 143 (9): 2907–16. PMID 2809212.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C (December 1995). "Molecular characterization of two murine eosinophil beta chemokine receptors". Journal of Immunology. 155 (11): 5299–305. PMID 7594543.
Combadiere C, Ahuja SK, Murphy PM (July 1995). "Cloning and functional expression of a human eosinophil CC chemokine receptor". The Journal of Biological Chemistry. 270 (28): 16491–4. doi:10.1074/jbc.270.28.16491. PMID 7622448.
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외부 링크

UCSC 게놈 브라우저의 인간 CCL4 유전자 위치 및 CCL4 유전자 세부 정보 페이지.

17번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1972563-2] Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.

[pmid11702067-3] Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nature Immunology. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. S2CID 7901253.

[pmid8525373-4] Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. Bibcode:1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID 8525373. S2CID 84062618.

[pmid11470920-5] Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 9283–8. Bibcode:2001PNAS...98.9283K. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920.

[Morrison_1974-6] Morrison MD, Lundquist PG (April 1974). "Labyrinthine morphology and temperature in cryosurgery (guinea pig)". Acta Oto-Laryngologica. 77 (4): 261–73. doi:10.1111/acel.12294. PMC 4364832. PMID 25620312.

[7] Morimoto T, Takagi H, Kondo T (January 1985). "Canine pancreatic allotransplantation with duodenum (pancreaticoduodenal transplantation) using cyclosporin A". Nagoya Journal of Medical Science. 47 (1–2): 57–66. PMID 3887178.

[pmid11278300-8] Guan E, Wang J, Norcross MA (April 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

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CCL4

네임스페이스

더

목차

함수

상호작용

참고 항목

참조

추가 읽기

외부 링크