호모사피엔스 종의 단백질 코딩 유전자
인터루킨-1 수용체 관련 키나아제 유사 2 는 인간에서 IRAK2 유전자 에 의해 암호화된 효소 다.[5] [6]
함수 IRAK2는 인터루킨-1 수용체 관련 키나아제 2를 암호화하고, 자극 시 인터루킨-1 수용체(IL1R)와 연관되는 두 가지 퍼팅 세린/트레오닌 키나제 중 하나이다. IRAK2는 NF-kappaB의 IL1 유도 상향규제에 참여하는 것으로 보고되었다.[6]
상호작용 IRAK2는 TRAF6 [5] [7] Myd88 과 상호작용 하는 것으로 나타났다.[5] [7] [8]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000134070 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000060477 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science . 278 (5343): 1612–5. Bibcode :1997Sci...278.1612M . doi :10.1126/science.278.5343.1612 . PMID 9374458 . ^ a b "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2" .^ a b Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family" . The Journal of Biological Chemistry . 274 (27): 19403–10. doi :10.1074/jbc.274.27.19403 PMID 10383454 . ^ Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature . 413 (6851): 78–83. Bibcode :2001Natur.413...78F . doi :10.1038/35092578 . PMID 11544529 . S2CID 4333764 . 추가 읽기 Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews . 9 (3–4): 221–37. doi :10.1016/S1359-6101(98)00018-5 . PMID 9918122 . Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB" . The Biochemical Journal . 339 ( Pt 2) (2): 227–31. doi :10.1042/0264-6021:3390227 . PMC 1220149 PMID 10191251 . Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family" . The Journal of Biological Chemistry . 274 (27): 19403–10. doi :10.1074/jbc.274.27.19403 PMID 10383454 . Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature . 413 (6851): 78–83. Bibcode :2001Natur.413...78F . doi :10.1038/35092578 . PMID 11544529 . S2CID 4333764 . McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1" . The Journal of Biological Chemistry . 277 (10): 7808–15. doi :10.1074/jbc.M108133200 PMID 11744690 . Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function" . The Journal of Biological Chemistry . 278 (9): 7607–16. doi :10.1074/jbc.M210455200 PMID 12493773 . Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling" . The Journal of Biological Chemistry . 278 (27): 24526–32. doi :10.1074/jbc.M303451200 PMID 12721283 . Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology . 346 (2): 411–22. doi :10.1016/j.jmb.2004.11.066 . PMID 15670593 . Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination" . The Journal of Biological Chemistry . 282 (46): 33435–43. doi :10.1074/jbc.M705266200 PMID 17878161 .
케모킨 CSF
인터페론
IFNAR(α/β, I) 고민자: 알빈터페론 인터페론 알파(인터페론 알파, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )인터페론 알파 2a 인터페론 알파 2b 인터페론 알파 n1 인터페론 알파콘-1 인터페론 알파-n3 인터페론 베타(IFN-β)( IFNB1 , IFNB3 )인터페론 베타 1a 인터페론 베타 1b 인터페론 카파(IFN-filename/changes/changes/changes, IFNK) 인터페론 오메가(IFN-Ω, IFNW1) 페긴터페론 알파-2a 페긴터페론 알파-2b IFNGR (1998, II) IFNLR (1998, III) 대신 여기 서 IL-28R(IFNLR)을 참조하십시오.
인터루킨 TGFβ TNF 다른이들