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atomikkus/README.md

About

I build the ML systems behind precision oncology at 4baseCare, where I joined as a founding member of the data science team and built out its ML infrastructure from zero. My work spans three areas:

  • Computational pathology — MIL and foundation-model pipelines (H-Optimus, Virchow2, UNI, CONCH) for biomarker prediction directly from whole-slide images, covering PD-L1, EGFR, MSI, and ALK fusion
  • Liquid biopsy — cfDNA methylation panel design for minimal residual disease detection in colorectal cancer
  • ML infrastructure — production pipelines on GCP (GKE, Cloud Run, Kafka, Prefect, Vertex AI) serving models at clinical scale

Selected work

Pathology foundation models Domain-adaptive continued pretraining of a ViT-L/14 encoder on thousands of whole-slide images, incorporating efficiency techniques from Kaiko's Midnight architecture.

Biomarker prediction from H&E Multi-model MIL pipelines (ABMIL, CLAM-SB, TransMIL) for predicting molecular biomarkers straight from tissue slides, benchmarked across multiple foundation model embeddings.

cfDNA methylation MRD panel A 9-marker methylation panel for colorectal cancer MRD detection, validated in-silico against TCGA and positioned against existing liquid biopsy assays.

cue An open-source terminal AI tool, built and maintained independently outside of work.

Stack

ML / Data

Infra

Other

Contribution snake
Outside of work: fermentation, watches, anime, and cat rescue.

Popular repositories Loading

  1. TMB_plotter TMB_plotter Public

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  2. stratagenome_cdss stratagenome_cdss Public

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    API for extraction of structured data from molecular pathology reports

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  4. atomikkus atomikkus Public

    Config files for my GitHub profile.

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    CWL CommandLineTool descriptions for biology/life-sciences related applications

    Common Workflow Language