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29 public repositories
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Big Life Lab Flow (BLLFlow) - a workflow for open, reproducible research. Includes support for PMML, DDI.
Whole-body PBPK model of digoxin as P-gp DDI victim drug
Whole-body PBPK model of midazolam as CYP3A4 DDI victim drug
Whole-body PBPK model of metformin (OCT2/MATE DDI victim drug)
Whole-body PBPK model of cimetidine (OCT2/MATE and CYP3A4 DDI perpetrator drug)
Whole-body PBPK model of itraconazole as CYP3A4 and P-gp DDI perpetrator drug
Whole-body PBPK model of tizanidine as a substrate of CYP1A2
Qualification of UGT-mediated drug-drug interactions
Whole-body PBPK model of hydrocodone
Whole-body PBPK model of alfentanil as CYP3A4 DDI victim drug
Whole-body PBPK model of fluvoxamine as CYP1A2 and CYP3A4 DDI perpetrator drug
Whole-body PBPK model of rifampicin as CYP3A4 and P-gp DDI perpetrator drug
Whole-body PBPK model of clarithromycin as CYP3A4 and P-gp DDI perpetrator drug
Whole-body PBPK model of omeprazole as a substrate of CYP2C19 and CYP3A4 and an inhibitor of CYP2C19.
Modeling of published clinical Cimetidine-Metformin-DDI studies for model evaluation
Whole-body PBPK model of s-mephenytoin as a substrate of CYP2C19
PBPK model of carbamazepine as CYP3A4 and CYP2B6 substrate and inducer
Whole-body PBPK model of moclobemide as a substrate and a moderate inhibitor of CYP2C19
Whole-body PBPK model of dapagliflozin
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