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33 stars written in C
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Linux kernel source tree

C 231,482 62,003 Updated Apr 30, 2026

A fast image processing library with low memory needs.

C 11,271 758 Updated Apr 30, 2026

Locally run an Instruction-Tuned Chat-Style LLM

C 10,152 860 Updated Apr 19, 2023

RNA-seq aligner

C 2,190 546 Updated Mar 18, 2025

A versatile pairwise aligner for genomic and spliced nucleotide sequences

C 2,166 460 Updated Apr 25, 2026

Tools (written in C using htslib) for manipulating next-generation sequencing data

C 1,889 610 Updated Apr 30, 2026

SRA Tools

C 1,329 279 Updated Apr 30, 2026

The Levenshtein Python C extension module contains functions for fast computation of Levenshtein distance and string similarity

C 1,279 156 Updated Aug 11, 2021

bedtools - the swiss army knife for genome arithmetic

C 1,030 295 Updated Mar 11, 2025

C library for high-throughput sequencing data formats

C 919 462 Updated Apr 30, 2026

Near-optimal RNA-Seq quantification

C 758 181 Updated Mar 16, 2026

🔬 BEDOPS: high-performance genomic feature operations

C 368 62 Updated Apr 29, 2025

Python package to read and write R RData and Rds files into/from pandas dataframes. No R or other external dependencies required.

C 336 25 Updated Apr 28, 2026

A flexible framework for rapid genome analysis and interpretation

C 319 115 Updated Oct 18, 2022

Short read de novo assembler using de Bruijn graphs, as published in: D.R. Zerbino and E. Birney. 2008. Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Genome Research, 1…

C 297 100 Updated Oct 13, 2025

Reads simulator

C 283 92 Updated Sep 3, 2021

A python extension for quick access to bigWig and bigBed files

C 243 55 Updated Jan 14, 2026

Quadratic Programming Solver

C 220 46 Updated Oct 24, 2024

miscellaneous scripts for bioinformatics/genomics that dont merit their own repo.

C 181 105 Updated Nov 26, 2018

Basic operations on the space of numerical functions defined on the genome using lazy evaluators for flexibility and efficiency

C 154 25 Updated Nov 6, 2024

Whole Genome Simulator for Next-Generation Sequencing

C 104 37 Updated Dec 27, 2025

1D/2D indexing and querying on bgzipped text file with a pair of genomic coordinates

C 92 15 Updated Jan 28, 2025
C 71 8 Updated Mar 7, 2019

An illumina paired-end and mate-pair short read simulator. This project attempts to model as many of the quirks that exist in Illumina data as possible. Some of these quirks include the potential f…

C 68 12 Updated Sep 10, 2014

De novo transcriptome assembler for short reads

C 64 9 Updated Mar 12, 2018

Robust Allele Specific Quantification and quality controL

C 41 20 Updated Dec 13, 2021

Rapid and robust analysis of RNA-Seq experiments.

C 32 7 Updated Apr 16, 2016

ImReP is a computational method for rapid and accurate profiling of the adaptive immune repertoire from regular RNA-Seq data.

C 29 13 Updated Oct 11, 2019

A Python interface to the BEDTools API using Cython

C 28 9 Updated Mar 16, 2011

Hera-T, a fast and accurate tool for estimating gene abundances in single cell data generated by the 10X-Chromium protocol

C 18 4 Updated Nov 9, 2021
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