OpenMS Thermo Raw File Bridge

A minimal C++/CLI bridge that embeds the .NET runtime to read Thermo .raw files via the official ThermoFisher vendor DLLs.

• Embeds .NET 9 runtime inside a native C++ DLL
• Loads ThermoFisher.CommonCore vendor DLLs
• Exposes a simple C++ API to read mass spectra from .raw files
• Tested on Windows x64

Python / C++ caller
       |
ThermoWrapper.dll  (C++/CLI bridge)
       |
ThermoFisher.CommonCore.RawFileReader.dll  (vendor .NET DLL)
       |
.raw file

RawBridge::GetScanCount(filePath)      // Total number of scans
RawBridge::GetRetentionTime(filePath, scanNum)  // Retention time in minutes
RawBridge::GetScanFilter(filePath, scanNum)     // Scan filter string
RawBridge::GetScan(filePath, scanNum)           // Full spectrum (m/z + intensity arrays)

• Windows x64
• .NET 9 runtime
• Visual Studio 2022 (to compile)
• ThermoFisher.CommonCore DLLs (from NuGet: ThermoFisher.CommonCore.RawFileReader)

MSBuild ThermoWrapper.sln /p:Configuration=Release /p:Platform=x64

import pythonnet
pythonnet.load("coreclr")
import clr, sys
sys.path.append(r"path\to\dlls")
clr.AddReference("ThermoWrapper")
from ThermoWrapper import RawBridge

count = RawBridge.GetScanCount(r"path\to\file.raw")
scan = RawBridge.GetScan(r"path\to\file.raw", 1)
print(scan.Masses, scan.Intensities)

• Windows x64 - Working
• Linux - In progress
• macOS - Planned