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22 stars written in C
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Reparent a running program to a new terminal

C 6,173 227 Updated Nov 20, 2025

Coz: Causal Profiling

C 4,444 167 Updated Feb 6, 2026

Implementations of SIMD instruction sets for systems which don't natively support them.

C 2,942 301 Updated Feb 5, 2026

Sandbox for securely executing untrusted programs

C 1,381 195 Updated Dec 11, 2025

A high-performance immutable mapping type for Python.

C 1,194 58 Updated May 20, 2025

Long read / genome alignment software

C 310 29 Updated Dec 16, 2025

Python library for handling efficiently sorted integer sets.

C 228 33 Updated Jan 29, 2026

NCLS. Basically a static interval-tree that is silly fast for both construction and lookups. Deprecated but maintained.

C 224 24 Updated Jul 4, 2025

Multithreading Library for Brotli, Lizard, LZ4, LZ5, Snappy and Zstandard

C 219 39 Updated Oct 4, 2025

A high performance python hash table library that is generally faster and consumes significantly less memory than Python Dictionaries

C 214 14 Updated Sep 3, 2023

Wavefront alignment algorithm (WFA): Fast and exact gap-affine pairwise alignment

C 199 16 Updated Mar 8, 2022

A modern compressor for genomic files (FASTQ, SAM/BAM/CRAM, VCF, FASTA, GFF/GTF/GVF, 23andMe...), up to 5x better than gzip and faster too

C 172 16 Updated Feb 3, 2026

A simple toolset for BED files (warning: CLI may change before bedtk becomes stable)

C 143 19 Updated Aug 24, 2025

A fast K-mer counter for high-fidelity shotgun datasets

C 140 18 Updated Jan 19, 2026

abPOA: an SIMD-based C library for fast partial order alignment using adaptive band

C 135 20 Updated Oct 26, 2025

BAMscale is a one-step tool for either 1) quantifying and normalizing the coverage of peaks or 2) generated scaled BigWig files for easy visualization of commonly used DNA-seq capture based methods.

C 73 17 Updated Dec 4, 2024

A reimplementation of the WaveFront Alignment algorithm at low memory

C 50 4 Updated May 22, 2024

Bioinformatics Open Source Sequence machine

C 32 7 Updated Aug 29, 2023

horizontal pileup

C 16 3 Updated Nov 11, 2022

Identifies duplicate reads. This tool locates and tags duplicate reads in a coordinate ordered SAM or BAM file.

C 15 2 Updated Jan 21, 2026

An extension to the wavefront algorithm that generalizes it to work on directed acyclic sequence graphs

C 9 Updated Feb 6, 2022

Plugins for use with HTSlib

C 9 8 Updated Mar 19, 2021