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saiyer123/README.md

Sahil Iyer

Bioinformatics × Clinical AI × Agentic Systems

M.S. Bioinformatics @ Johns Hopkins · B.A. Bioinformatics @ UC San Diego
Building AI that actually ships in clinical settings.


What I'm working on

  • CTO @ Continuum Health — Full-stack clinical documentation platform replacing legacy care-plan workflows for an Adult Day Health Care center. Automated 116-page IPC reassessment packets (40+ hrs → <5 min), Azure OpenAI dictation + SOAP note generation, full billing pipeline across Kaiser / Medi-Cal / LA Care.

  • CTO & @ C-URE-PAIN — Clinical AI platform for pain diagnostics: real-time 3D WebGL pain mapping, XGBoost/RF ML pipeline on 1,500+ physician-labeled cases (78% balanced accuracy), LangGraph agentic orchestration with human-in-the-loop review, automated CPT/ICD clinical reports.

  • Agentic AI Scientist @ A*STAR IMCB (Singapore) — LLM-agentic workflows over Cox survival models trained on the Singapore Longitudinal Aging Study (~6k participants). RAG-grounded chat, lifestyle simulation, biological age platform deployed at international conferences.


Tech stack

ML / AI
PyTorch TensorFlow scikit-learn XGBoost HuggingFace LangGraph OpenAI LoRA BERT

Languages & Frameworks
Python TypeScript R SQL Bash FastAPI React Node.js Three.js

Infrastructure
AWS Azure Docker PostgreSQL Nextflow

Data & Bioinformatics
pandas NumPy Matplotlib BioPython Jupyter

Selected work

Project What it is Stack
BioAge Platform Biological age prediction from 5 validated models (Cox survival, functional, body systems, frailty, cognitive). Trained on SLAS 2,778-participant longitudinal study. Deployed at A*STAR conferences. FastAPI · React · OpenAI · RAG · AWS
Continuum Health (private) Clinical documentation platform for ADHC center — IPC care plans, AI-generated SOAP notes, billing pipeline React · TypeScript · FastAPI · Azure OpenAI
C-URE-PAIN (private) Pain diagnostic AI — 3D body mapping, XGBoost triage, LangGraph agentic orchestration, automated clinical reports React · Three.js · XGBoost · LangGraph · FastAPI
HLA Compatibility ML (Immunomatics) Biologically-informed ML pipeline for 30K+ HLA allele pairs — BLOSUM62 features, Siamese embeddings, 78% AUC-ROC Python · scikit-learn · pandas
GRPO Policy Optimization (Johns Hopkins) Multi-turn RL system for LLM sequential decision-making; GRPO-style optimization via Hugging Face TRL + Unsloth; 40% improvement over supervised baseline PyTorch · HuggingFace TRL · Unsloth
BC-Design Benchmarking (Gerstein Lab, Yale) 6-metric evaluation suite for inverse protein folding; curated 5K+ PDB/CATH structures; diagnosed 40% degradation on sequences >500 residues PyTorch-Lightning · BioPython

Background

I'm a bioinformatician who ended up deep in clinical AI engineering — building systems that go from raw data to production decisions in real healthcare settings. My work sits at the intersection of:

  • Agentic AI — LangGraph orchestration, RAG, tool-use, RLHF/GRPO
  • Clinical ML — survival models, diagnostic triage, HIPAA-compliant pipelines
  • Bioinformatics — protein structure, HLA immunogenetics, longitudinal aging studies

Currently finishing my M.S. in Bioinformatics at Johns Hopkins while building at two healthcare AI startups.


sahil.ajay.iyer@gmail.com · LinkedIn

Pinned Loading

  1. GRPO-Sparse-Robotics GRPO-Sparse-Robotics Public

    Jupyter Notebook

  2. Beyond-20Q-IR-Transfer Beyond-20Q-IR-Transfer Public

    Jupyter Notebook

  3. CDK4 CDK4 Public

    Python

  4. DataLoader.MultimodalLLM DataLoader.MultimodalLLM Public

    Python