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83 stars written in Python
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The best ChatGPT that $100 can buy.

Python 42,319 5,463 Updated Feb 5, 2026

Build and share delightful machine learning apps, all in Python. 🌟 Star to support our work!

Python 41,582 3,251 Updated Feb 2, 2026

Composable transformations of Python+NumPy programs: differentiate, vectorize, JIT to GPU/TPU, and more

Python 34,800 3,401 Updated Feb 5, 2026

Prefect is a workflow orchestration framework for building resilient data pipelines in Python.

Python 21,550 2,095 Updated Feb 5, 2026

A reactive notebook for Python — run reproducible experiments, query with SQL, execute as a script, deploy as an app, and version with git. Stored as pure Python. All in a modern, AI-native editor.

Python 18,905 900 Updated Feb 5, 2026

🦉 Data Versioning and ML Experiments

Python 15,339 1,276 Updated Feb 1, 2026

Open source code for AlphaFold 2.

Python 14,244 2,552 Updated Jan 15, 2026

Pyodide is a Python distribution for the browser and Node.js based on WebAssembly

Python 14,195 991 Updated Jan 29, 2026

Minimal reproduction of DeepSeek R1-Zero

Python 12,693 1,548 Updated Apr 24, 2025

[CVPR 2025 Best Paper Award] VGGT: Visual Geometry Grounded Transformer

Python 12,401 1,330 Updated Oct 11, 2025

The little ASGI framework that shines. 🌟

Python 11,894 1,105 Updated Feb 1, 2026

AlphaFold 3 inference pipeline.

Python 7,570 1,098 Updated Feb 5, 2026

Democratizing Deep-Learning for Drug Discovery, Quantum Chemistry, Materials Science and Biology

Python 6,511 2,061 Updated Jan 21, 2026

data load tool (dlt) is an open source Python library that makes data loading easy 🛠️

Python 4,881 447 Updated Feb 5, 2026

Official repository for the Boltz biomolecular interaction models

Python 3,720 739 Updated Oct 3, 2025

Code for running RFdiffusion

Python 2,733 568 Updated Nov 20, 2025

Persistent remote applications for X11; screen sharing for X11, MacOS and MSWindows.

Python 2,674 220 Updated Feb 5, 2026

RamaLama is an open-source developer tool that simplifies the local serving of AI models from any source and facilitates their use for inference in production, all through the familiar language of …

Python 2,569 300 Updated Feb 5, 2026

Distributed self-replicating programs in Python

Python 2,484 206 Updated Feb 5, 2026

A 21 century R console

Python 2,237 86 Updated May 15, 2025

A Pure Python, React-style Framework for Scaling Your Jupyter and Web Apps

Python 2,155 183 Updated Feb 5, 2026

Shiny for Python

Python 1,682 118 Updated Feb 4, 2026

Implementation of DiffDock: Diffusion Steps, Twists, and Turns for Molecular Docking

Python 1,427 341 Updated May 2, 2025

BirdNET analyzer for scientific audio data processing.

Python 1,387 242 Updated Feb 5, 2026

🧬 gget enables efficient querying of genomic reference databases

Python 1,094 82 Updated Feb 5, 2026

Cloud-native genomic dataframes and batch computing

Python 1,046 258 Updated Feb 5, 2026
Python 936 81 Updated Dec 24, 2025

A WDL, CWL and Python API supporting easy-to-use workflow engine. It is scalable, efficient and cross-platform (Linux/macOS).

Python 927 245 Updated Feb 4, 2026

Standardized data set for machine learning of protein structure

Python 908 137 Updated Nov 18, 2020

Pythonic tool for orchestrating machine-learning/high performance/quantum-computing workflows in heterogeneous compute environments.

Python 855 110 Updated Feb 5, 2026
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