석소체/내소체 칼슘 ATPase 3은 사람 에게서 ATP2A3 유전자에 [5] [6] 효소 이다.
이 유전자는 SERCA Ca-ATPases 2+ 중 하나를 암호화하는데, SERCA Ca-ATPases는 세포의 석소체 또는 소포체 내에 위치 한 세포 내 펌프이다. SERCA3 발현은 원래 비근육성으로 설명되었지만 최근 심근세포 에서 관찰되었다. 이 효소는 세포질 에서 석소체 내강 으로의 칼슘 이동과 결합된 ATP의 가수 분해를 촉매하고 근육 흥분 및 수축과 관련된 칼슘 격리에 관여합니다. 대체 스플라이싱은 SERCA3a라는 이름의 다른 아이소폼을 [6]
암 ATP2A3 유전자는 다양한 악성 종양 [7] 전형성 병변에서 파생된 인간 유두종 바이러스 양성 신생물 각화세포 에서 점진적 으로 하향 조절되는 것이 관찰되었다. 이러한 이유로, ATP2A3는 종양 발생과 관련될 가능성이 높으며 자궁 경부 전형성 병변 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000074370 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020788 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+ -ATPase 3 gene" . Biochem J . 318 (2): 689–99. doi :10.1042/bj3180689 . PMC 1217674 PMID 8809064 . ^ a b "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous" .^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol . 230 (4): 802–812. doi :10.1002/jcp.24808 . PMID 25205602 . S2CID 24986454 .
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