닐스13

GNA13
닐스13
Protein GNA13 PDB 1zcb.png
사용 가능한 구조물
PDB직교 검색: PDBe RCSB
식별자
별칭NECT13, G13, G단백질소단위 알파13, HG1N
외부 IDOMIM: 604406 MGI: 95768 HomoloGene: 55976 GeneCard: WIST13
직교체
종인간마우스
엔트레스

10672

14674

앙상블

ENSG00000120063

ENSMUSG00000020611

유니프로트

Q14344

P27601

RefSeq(mRNA)

NM_001282425
NM_006572

NM_010303
NM_001359034

RefSeq(단백질)

NP_001269354
NP_006563

NP_034433
NP_001345963

위치(UCSC)Cr 17: 65.01 – 65.06MbChr 11: 109.25 – 109.29Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

구아닌 뉴클레오티드 결합 단백질 서브유닛 알파-13은 인간에게 있어 WIS13 유전자에 의해 암호화된 단백질이다.[5][6]

상호작용 및 함수

WENT1313 유전자는 G G단백질 알파 서브유닛을 인코딩한다.이 두 단백질은 닐스12와 함께 이단백질 G단백질 알파 서브유닛의 네 종류 중 하나로 구성된다.[7]이질성 G 단백질은 세포 표면 G 단백질 결합 수용체가 세포 내 기능을 조절하기 위한 세포 내 신호 경로로 감지한 호르몬과 신경전달물질 신호에 기능한다.G단백질 알파 서브유닛은 구아닌 뉴클레오티드와 규제의 사이클에서 결합하고 기능하며, GTP에 바인딩되었을 때는 활성하지만, GDP에 바인딩되었을 때는 비활성화되고 G 베타감마 콤플렉스와 연관된다.[8][9]

활성 GTP 바운드 G12 알파 서브유닛은 ARHGEF1, [10][11][12]ARHGEF11 [13][14]및 ARHGEF12와 상호 작용하여 활성화한다.[15][16]이러한 ARHGEF 단백질은 액틴 시토스켈레톤을 조절하기 위해 Rho 소형 GTPas에 대한 구아닌 뉴클레오티드 교환 인자 역할을 한다.[17]

NECT13은 AKAP3, [18]RIC8A,[19] Radixin과 상호작용하는 것으로 나타났다.[21]

임상적 유의성

이 유전자의 재발한 돌연변이는 큰 B세포 림프종을 확산시키는 사례와 연관되어 왔다.[22][23]

참고 항목

참조

  1. ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000120063 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000020611 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (Mar 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Molecular and Cellular Biochemistry. 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744. S2CID 8911988.
  6. ^ "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13".
  7. ^ Strathmann MP, Simon MI (1991). "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6. Bibcode:1991PNAS...88.5582S. doi:10.1073/pnas.88.13.5582. PMC 51921. PMID 1905812.
  8. ^ Gilman, AG (1987). "G proteins: transducers of receptor-generated signals". Annual Review of Biochemistry. 56: 615–649. doi:10.1146/annurev.bi.56.070187.003151. PMID 3113327.
  9. ^ Rodbell, M (1995). "Nobel Lecture: Signal transduction: Evolution of an idea". Bioscience Reports. 15 (3): 117–133. doi:10.1007/bf01207453. PMID 7579038. S2CID 11025853.
  10. ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. S2CID 6798899.
  11. ^ Bhattacharyya R, Wedegaertner PB (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Letters. 540 (1–3): 211–6. doi:10.1016/s0014-5793(03)00267-9. PMID 12681510. S2CID 84132104.
  12. ^ Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
  13. ^ Fukuhara, S; Murga, C; Zohar, M; Igishi, T; Gutkind, JS (1999-02-26). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". Journal of Biological Chemistry. 274 (9): 5868–5879. doi:10.1074/jbc.274.9.5868. PMID 10026210.
  14. ^ Rümenapp, U; Blomquist, A; Schwörer, G; Schablowski, H; Psoma, A; Jakobs, KH (1999-10-15). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Letters. 459 (3): 313–318. doi:10.1016/s0014-5793(99)01270-3. PMID 10526156. S2CID 8529412.
  15. ^ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164. S2CID 7300556.
  16. ^ Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. Bibcode:2003PNAS..100..733S. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  17. ^ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45. doi:10.1016/0898-6568(96)00048-4. PMID 8842523.
  18. ^ Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology. 11 (21): 1686–90. doi:10.1016/s0960-9822(01)00530-9. PMID 11696326. S2CID 19027128.
  19. ^ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  20. ^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.
  21. ^ Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of radixin by G13 protein alpha subunit". The Journal of Biological Chemistry. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
  22. ^ Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature. 476 (7360): 298–303. Bibcode:2011Natur.476..298M. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.
  23. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. Bibcode:2012PNAS..109.3879L. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

추가 읽기

외부 링크

  • PDBe-KB에서 UniProt: P27601(Mouse Guanine nucleotide-binding 단백질 서브유닛 알파-13)에 대한 PDB의 모든 구조 정보 개요.

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.